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Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior

Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior

Objective

Emerging evidence indicates that the gut microbiome contributes to our ability to extract energy from the diet and influences development and function of the immune, endocrine and nervous systems, which regulate energy balance and behaviour. This has led to hypothesize that developing microbiome-based dietary interventions can be cost-effective measures to prevent diet-related and behavioural disorders. Yet this approach is restricted in practice by a lack of understanding of the specific species that contribute to these disorders and their interactions with host and lifestyle determinants. To progress beyond the state of the art, the MyNewGut proposal aims to: (1) shed light on the contribution of the human microbiome to nutrient metabolism and energy expenditure; (2) identify microbiome-related features that contribute to or predict obesity and associated disorders in human epidemiological studies; (3) understand how the microbiome is influenced by environmental factors and its role in brain and immune development and function in humans; and (4) provide proof-of-concept of the disease risk-reduction potential of dietary intervention with new foods/ingredients targeting the gut microbiome in humans. To this end, a translational multidisciplinary research strategy will be developed, combining experts in omic-technologies and all other scientific disciplines required. Consequently, the MyNewGut proposal will contribute to developing new approaches to prevent diet-related diseases (metabolic syndrome and obesity) and behavioural disorders through lifestyle changes, intake of pro- and prebiotics and semi-personalised and innovative food products. This will ultimately contribute to increasing the competitiveness of the European food industry and provide consumers with reliable claims on foods. Results will also help inform new strategies on public health, support EU legislation and improve the position of the EU in the field of food-related disease prevention.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 713 293

Administrative Contact

María ángeles López Vázquez (Ms.)

Participants (29)

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ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 1 002 940

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 893 194

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 548 994

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

EU Contribution

€ 497 914

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 450 005

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 451 550

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

EU Contribution

€ 441 926

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands

EU Contribution

€ 382 925

KLINIKUM DER UNIVERSITAET REGENSBURG

Germany

EU Contribution

€ 315 573

THE UNIVERSITY OF READING

United Kingdom

EU Contribution

€ 266 403

MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 224 756

LEIBNIZ-INSTITUT FUR PRAVENTIONSFORSCHUNG UND EPIDEMIOLOGIE - BIPS GMBH

Germany

EU Contribution

€ 194 439

UNIVERSIDAD DE GRANADA

Spain

EU Contribution

€ 150 900

INSTITUTE FOR FOOD TECHNOLOGY OF NOVI SAD

Serbia

EU Contribution

€ 69 840

EUROPEAN FOOD INFORMATION COUNCIL

Belgium

EU Contribution

€ 281 340

STICHTING EFFOST

Netherlands

EU Contribution

€ 70 000

ICC-INTERNATIONAL ASSOCATION FOR CEREAL SCIENCE AND TECHNOLOGY

Austria

EU Contribution

€ 110 800

CARGILL HAUBOURDIN SAS

France

EU Contribution

€ 217 364

BARILLA G. E R. FRATELLI SPA

Italy

EU Contribution

€ 149 930

LALLEMAND SAS

France

EU Contribution

€ 66 240

CORPORACION ALIMENTARIA PENASANTA - CAPSA

Spain

EU Contribution

€ 200 562

ALIMENTARY HEALTH LTD

Ireland

EU Contribution

€ 91 600

LOMAN FOOD CONSULTING BV

Netherlands

EU Contribution

€ 155 625

AKCIONARSKO DRUSTVO MLEKARA SUBOTICA

Serbia

EU Contribution

€ 25 155

COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Australia

BAYLOR COLLEGE OF MEDICINE

United States

University of Michigan/Autophagy Journal

United States

THE UNIVERSITY OF AUCKLAND

New Zealand

Queen's University at Kingston

Canada

Project information

Grant agreement ID: 613979

Status

Closed project

  • Start date

    1 December 2013

  • End date

    30 November 2018

Funded under:

FP7-KBBE

  • Overall budget:

    € 13 006 815,40

  • EU contribution

    € 8 973 268

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain