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Fast, cost-effective, user-friendly point of care (POC) instrument for detection of respiratory pathogens, including Streptococcus pneumoniae

Objective

Molecular techniques such as PCR (polymerase chain reaction) are becoming increasingly used for the detection of respiratory pathogens, due to their high accuracy and relatively fast turnaround time (hours). Their utilization can result in early and specific treatment, contribute to better patient outcomes and reduce length of hospital stay. However, implementation of rapid molecular diagnostics remains limited to large, centralised laboratories which can afford the requirements of dedicated PCR laboratory space, specialized personnel and costly equipment and consumables. Even in central laboratories, timely diagnosis may be undermined by delays during sample transport to the setting and batching practices oriented to save consumables. There is a need for a fast, cost-effective, user-friendly molecular diagnostic point-of-care (POC) instrument for near-patient use at small to medium size hospitals, and decentralized clinical laboratories. The RESPOC platform will be a novel solution designed to detect bacterial and viral respiratory pathogens in less than one hour. Based on the development of DNA extraction and DNA amplification methods integrated into a low-cost microfluidic lab-on-a-chip (LoC) consumable, the platform will deliver results automatically by insertion of the disposable LoC into a small footprint reading instrument. Initially it will identify the target respiratory pathogens Streptococcus pneumoniae (pneumococcus) and Bordetella pertussis. Pre-clinical validation and demonstration of the RESPOC instrument will be performed at the facilities of the RTD hospital participant and at the facilities of the SME end-users to ensure adequate diagnostic performance and usability.

Field of science

  • /social sciences/social and economic geography/transport

Call for proposal

FP7-SME-2013
See other projects for this call

Funding Scheme

BSG-SME - Research for SMEs

Coordinator

HOSPITAL SANT JOAN DE DÉU
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat
Spain
Activity type
Research Organisations
EU contribution
€ 26 000,82
Administrative Contact
Arnalte Roser (Ms)

Participants (7)

N.T. LABORATORY SRL
Italy
EU contribution
€ 231 839,21
Address
Via Baldanzese 35
50041 Calenzano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Matteo Fallani (Dr.)
JCB. ELECTROMECANICA SL
Spain
EU contribution
€ 222 276,66
Address
Calle Victor Pradera 45
08940 Cornella De Llobregat
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Narcís Clavell (Mr.)
LIONEX GMBH

Participation ended

Germany
EU contribution
€ 110 680,21
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mahavir Singh (Prof.)
SURESCREEN DIAGNOSTICS LIMITED
United Kingdom
EU contribution
€ 225 382,08
Address
Prime Parkway 1 Prime Enterprise 1
DE1 3QB Derby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alex Campbell (Mr.)
NTRAM GENERAL S.A.
Spain
EU contribution
€ 48 844,97
Address
Calle Victor Pradera 45
08940 Cornella De Llobregat Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elisenda Lamana Garcia (Ms.)
HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v.
Germany
EU contribution
€ 32 994
Address
Wilhelm-schickard-strasse 10
78052 Villingen
Activity type
Research Organisations
Administrative Contact
Saskia Becker (Mrs.)
PATHOFINDER BV
Netherlands
EU contribution
€ 204 079,32
Address
Randwycksingel 45
6229 EG Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guus Simons (Dr.)