CORDIS
EU research results

CORDIS

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Programming synthetic networks for bio-based production of value chemicals

Project information

Grant agreement ID: 613745

Status

Closed project

  • Start date

    1 December 2013

  • End date

    30 November 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 9 372 087,20

  • EU contribution

    € 7 188 402

Coordinated by:

DANMARKS TEKNISKE UNIVERSITET

Denmark

Objective

The global chemical industry is transitioning from petrochemical production processes to bio-based production processes. This transition creates a clear market need for technologies that reduce the development time and cost of cell factories. PROMYS will develop, validate and implement a novel synthetic biology platform technology termed ligand responsive regulation and selection systems. Ligand responsive regulation and selection systems are biological devices that integrate biological sensing modules, within larger regulatory networks to control cellular programs. This technology will drastically accelerate the construction, optimization and performance of cell factories by enabling industrial users to impose non-natural objectives on the engineered cell factory. PROMYS will address three major challenges in metabolic engineering that limit the development of new cell factories:
1) Synthetic pathway construction
2) Cell factory optimization
3) Control of populations during fermentation

Ligand responsive regulation and selection systems will directly couple the presence of a desired chemical product or flux state within a cell, to the survival of the cell. As such, they allow the in vivo identification of the needle (e.g. functional pathway or optimized cell factories) in a haystack (e.g. large libraries). In addition, the technology developed in PROMYS will be applied to deliver increased fermentation yields by continuously selecting for high yielding cell factories within the fermentation population.
PROMYS is industry driven and designed such that the expected innovations of each work package have a direct commercialization partner, which is willing to commit the necessary resources to develop commercial products from the innovation.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

DANMARKS TEKNISKE UNIVERSITET

Address

Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 312 890

Administrative Contact

Birte Rasmussen

Participants (6)

BACMINE SL

Spain

EU Contribution

€ 813 471

TECHNISCHE UNIVERSITAT DARMSTADT

Germany

EU Contribution

€ 904 418

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 1 004 400

THE UNIVERSITY OF WARWICK

United Kingdom

EU Contribution

€ 722 423

EVOLVA AG

Switzerland

EU Contribution

€ 712 800

BIOSYNTIA APS

Denmark

EU Contribution

€ 718 000

Project information

Grant agreement ID: 613745

Status

Closed project

  • Start date

    1 December 2013

  • End date

    30 November 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 9 372 087,20

  • EU contribution

    € 7 188 402

Coordinated by:

DANMARKS TEKNISKE UNIVERSITET

Denmark

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