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Systems Biology to Identify Molecular Targets for Vascular Disease Treatment

Objective

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular targets for therapeutic intervention.
The consortium is based on established multidisciplinary European research networks, including specialists in pre-clinical and clinical research, omics technologies, and systems biology from research intensive SMEs and academia; partners synergistically provide access to an extensive number of selected population-based cohorts and associated datasets, cutting edge modeling and simulation methods, and established cardiovascular disease (CVD) animal models and patient cohorts. The coordinated application of these tools and know-how will identify pathophysiological mechanisms and key molecules responsible for onset and progression of CVD and validate their potential to serve as molecular targets for therapeutic intervention. To this end, the consortium will also use unique resources to evaluate molecular homology between the available model systems and human disease, which will yield reliable essential preclinical research tools to explore proof of concepts for therapeutic intervention studies and ultimately translate relevant results into novel therapeutic approaches.
Collectively, SysVasc will identify and validate novel biology-driven key molecular targets for CVD treatment. Major scientific, societal and economic impact is expected including, but not limited to, providing a valuable resource to further CVD research, and enhance competitiveness of participating SMEs and European health industry in general by translating knowledge into “innovative services” in therapeutic target and drug research.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

MEDIZINISCHE UNIVERSITAT GRAZ
Address
Auenbruggerplatz 2
8036 Graz
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 483 025,08
Administrative Contact
Burkert Pieske (Prof.)

Participants (18)

MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 883 600
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Harald Mischak (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 400 407
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 789 166
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Delles (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 378 560
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Jean-Loup Bascands (Dr.)
BAKER HEART AND DIABETES INSTITUTE
Australia
Address
Commercial Road 75 Victoria
3104 Melbourne
Activity type
Research Organisations
Administrative Contact
Karlheinz Peter (Prof.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 257 060,40
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Stevens (Dr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 250 124,40
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 222 160
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
Administrative Contact
Dimitris Raptis (Mr.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 239 564
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Florian Lang (Prof.)
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
EU contribution
€ 390 080
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
Administrative Contact
Ioannis Xenarios (Prof.)
UNIVERSITY OF BRITISH COLUMBIA

Participation ended

Canada
Address
Agronomy Road 102-6190
V6T1Z1 Vancouver
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chris Overall (Prof.)
BIOCRATES LIFE SCIENCES AG
Austria
EU contribution
€ 342 130
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rania Kovaiou (Dr.)
EAGLE GENOMICS LIMITED
United Kingdom
EU contribution
€ 317 296,50
Address
Biodata Innovation Centre, Wellcome Genome Campus,
CB10 1DR Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Abel Ureta-Vidal (Dr.)
GENOMIC INVESTMENTS BV
Netherlands
Address
Plesmanlaan 1D
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Janssen Bart (Prof.)
BIOLUTION GMBH
Austria
EU contribution
€ 76 184
Address
Helmut Qualtinger Gasse 2/2
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iris Grünert (Dr.)
UNIVERSITY OF PLYMOUTH
United Kingdom
EU contribution
€ 339 648
Address
Drake Circus
PL4 8AA Plymouth
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Paisey (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 396 447,62
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martina Eickmann (Mrs.)
GenomeScan B.V.
Netherlands
EU contribution
€ 210 960
Address
Plesmanlaan 1D
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bart Janssen (Prof.)