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Multiscale modeling and simulation of biological and artificial
locomotion at the micron scale: from metastatic tumor cells and unicellular swimmers to bioinspired microrobots

Objective

The project addresses the mechanical bases of cell motility by swimming and crawling, and the possibility of replicating the principles behind them in artificial systems.

The goals are to elucidate some key mechanisms governing bio-locomotion. In particular, actin- based motility of crawling cells and motility by swimming of unicellular organisms will be studied both in general and with reference to concrete model systems.

The study of biological examples of swimming and crawling motility will be used to produce a prototype of a micron-scale bio-inspired motile micro-robot exploiting the miniaturization that becomes possible from the extensive use of active materials.

This is a multi-disciplinary research project. The themes arise from the Mechanics of Soft and Bio- logical Matter. The methods are those of Computational Engineering, and take advantage of innovative techniques from Applied Mathematics. The planned research activities rest on the development of new tools and methods in mathematical modeling, numerical simulation, data acquisition on biological systems, and on the construction of prototype devices.

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Field of science

  • /natural sciences/mathematics/applied mathematics
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /natural sciences/mathematics

Call for proposal

ERC-2013-ADG
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Address
Via Bonomea 265
34136 Trieste
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 302 270
Principal investigator
Antonio De Simone (Prof.)
Administrative Contact
Gabriele Rizzetto (Mr.)

Beneficiaries (1)

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Italy
EU contribution
€ 1 302 270
Address
Via Bonomea 265
34136 Trieste
Activity type
Higher or Secondary Education Establishments
Principal investigator
Antonio De Simone (Prof.)
Administrative Contact
Gabriele Rizzetto (Mr.)