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Multidisciplinary Approaches to Translational Research In Conduct Syndromes

Multidisciplinary Approaches to Translational Research In Conduct Syndromes

Objective

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypothesis that reactive and instrumental aggression result from aberrant autonomic reactivity coupled to the differential impairment of three basic neural functions: 1) regulation of control mechanisms of aggression, 2) emotional value rating of others, and 3) empathy and moral decision making. MATRICS will employ the same psychological tasks assessing 1), 2) and 3) in animal aggression models and human CD samples concurrent with the assessment of neural, neurochemical, (epi)-genetic and autonomic nervous system markers. These data will be integrated with matching expression profiling from neurons derived from CD IPSCs. MATRICS also examines how environmental risks, whether or not they interact with genetic factors, are translated in epigenetic and neural changes. MATRICS will data-mine existing large integrated imaging-genetics cohorts (NeuroIMAGE; IMAGEN) and prospective cohorts (TRAILS; ALSPAC) with follow-up into adulthood and the (epi)genetic profiling of the PERS CD cohort, and collect a large new CD cohort and controls for collection of MRI, (epi)-genetic, biochemical and environmental measures. Bayesian machine learning tools will integrate multi-source and multi-level data, and generate predictive algorithms of persistent aggression into adulthood. MATRICS will identify new potentially ‘druggable’ targets, develop novel animal models and conduct pilot medication and neuro/biofeedback studies in high-risk and CD patients. MATRICS builds on existing fruitful EU collaborations which maximises feasibility and successful output.

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 206 757,61

Administrative Contact

Maarten Van Langen (Mr.)

Participants (19)

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 270 740

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 267 900

GENOWAY S.A.

France

EU Contribution

€ 65 630

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 886 928

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

EU Contribution

€ 238 675

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 15 445,76

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 184 288

THE UNIVERSITY OF EXETER

United Kingdom

EU Contribution

€ 300 000

UNIVERSITA DEGLI STUDI DI CAGLIARI

Italy

EU Contribution

€ 158 240,24

neuroConn GmbH

Germany

EU Contribution

€ 98 700

UNIVERSITAET ULM

Germany

EU Contribution

€ 54 508

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER

France

EU Contribution

€ 49 200

PHENOSYS GMBH

Germany

EU Contribution

€ 60 000

Concentris Research Management GmbH

Germany

EU Contribution

€ 313 700

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 18 838,09

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 17 869,30

CERTAIN INDEXES LIMITED

United Kingdom

EU Contribution

€ 167 580

DRUG TARGET ID BV

Netherlands

EU Contribution

€ 50 000

Fondazione Stella Maris

Italy

EU Contribution

€ 75 000

Project information

Grant agreement ID: 603016

Status

Closed project

  • Start date

    1 March 2014

  • End date

    28 February 2019

Funded under:

FP7-HEALTH

  • Overall budget:

    € 5 839 077,93

  • EU contribution

    € 4 500 000

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands