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Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver disease

Objective

The CONNECT project intends to contribute to the substantiation of the controversial scientific concept stating that hemichannels consisting of connexin32 and connexin43 as well as pannexin1 channels act as pathological pores. This hypothesis will be verified in the specific context of cell death and inflammation, both which are key features of acute liver failure and liver fibrosis. As such, the project is organised in 3 workpackages. In the first workpackage, connexin32, connexin43 and pannexin1 expression and activity will be studied in human and animal diseased liver tissue. The second workpackage is targeted towards the in vitro characterisation of recently generated inhibitors of hemichannels consisting of connexin32 and connexin43 as well as pannexin1 channels, namely Gap24, Gap19 and 10Panx1, respectively. Particular attention will be paid to their target selectivity and potential to reduce cell death and inflammation in liver-based in vitro models. The goal of the third workpackage is to test the in vivo extrapolation of the established in vitro findings. To this end, Gap24, Gap19 and 10Panx1 will be administered to animal models of acute liver failure or liver fibrosis, followed by evaluation of their outcome on cell death, inflammation and clinically relevant read-outs. The CONNECT project is anticipated to significantly impact the connexin and pannexin research area, as it foresees the development and optimisation of new tools and technology to study connexin hemichannels and pannexin channels. The clinical utility of this high risk/high gain project is dual, as it aspires the establishment of novel drug targets and tissue biomarkers for, respectively, the treatment and diagnosis of liver disease. However, given the generic nature of the driving concept, the outcome of the CONNECT project is equally of clinical relevance for a plethora of other pathologies.
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Principal Investigator

Mathieu Frederick Alexander Vinken (Prof.)

Host institution

VRIJE UNIVERSITEIT BRUSSEL

Address

Pleinlaan 2
1050 Brussel

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 473 928,80

Principal Investigator

Mathieu Frederick Alexander Vinken (Prof.)

Administrative Contact

Nik Claesen (Mr.)

Beneficiaries (1)

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VRIJE UNIVERSITEIT BRUSSEL

Belgium

EU Contribution

€ 1 473 928,80

Project information

Grant agreement ID: 335476

Status

Closed project

  • Start date

    1 March 2014

  • End date

    28 February 2019

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 473 928,80

  • EU contribution

    € 1 473 928,80

Hosted by:

VRIJE UNIVERSITEIT BRUSSEL

Belgium