CORDIS
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CORDIS

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Systematic investigation of epistasis in molecular evolution

Project information

Grant agreement ID: 335980

Status

Closed project

  • Start date

    1 January 2014

  • End date

    31 December 2018

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 461 576

  • EU contribution

    € 1 461 576

Hosted by:

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA

Austria

Objective

Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictions of the extent of this phenomenon in nature accurate? The present project aims to take a swing at answering, at least partially, these basic questions of epistasis in molecular evolution. Within our work we plan to address these issues using computational approaches, systematic fitness assays of engineered orthologous genotypes and experimental functional assays of specific cases of epistasis identified by evolutionary analysis. By tackling these goals and utilising this array of approaches the projects aims to create a synthesis between theory and experimentation under the confines of a single laboratory that will allow us to study this phenomenon in a systematic fashion on the interface of different fields and methodologies.

Principal Investigator

Fyodor Kondrashov (Dr.)

Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA

Address

Am Campus 1
3400 Klosterneuburg

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 303 788,58

Principal Investigator

Fyodor Kondrashov (Dr.)

Administrative Contact

Barbara Abraham (Mrs.)

Beneficiaries (2)

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA

Austria

EU Contribution

€ 303 788,58

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 1 157 787,42

Project information

Grant agreement ID: 335980

Status

Closed project

  • Start date

    1 January 2014

  • End date

    31 December 2018

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 461 576

  • EU contribution

    € 1 461 576

Hosted by:

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA

Austria