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GENETIC EFFECTS OF ENVIRONMENTAL CHEMICALS.

Ziel

STUDY OF MOLECULAR INTERACTIONS OF ENVIRONMENTAL MUTAGENS AND CARCINOGENS AT DNA LEVEL.
The continued study of mutant frequencies enlarges and reinforces the quality of our database, with a view to using it as a biomonitoring system. Validation of the system was achieved by testing groups of individuals known to have been exposed to genotoxic agents. This enabled the limits of the system to be determined and also gave information on the nature of the mutants recovered in this system.
THE PROJECT IS INTENDED TO EVALUATE THE POTENTIAL OF THE SYSTEM FOR DETECTING 6-THIOGUANINE RESISTANT MUTANTS AMONGST HUMAN CIRCULATING T LYMPHOCYTES TO ACT AS A POPULATION MONITOR FOR SOMATIC MUTATIONS.

VALIDATION TRIALS WILL BE UNDERTAKEN USING INDIVIDUALS KNOWN TO BE EXPOSED GENOTOXICANTS OR AGENTS WHICH PERTURBE THE HAEMOTOLOGICAL STATUS.

THE MUTANTS WHICH BECOME AVAILABLE IN THIS WAY WILL BE USED TO INVESTIGATE THE NATURE OF THE MUTATIONAL EVENT AND THE ORIGIN OF THE MUTANTS.

Wissenschaftliches Gebiet

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Aufforderung zur Vorschlagseinreichung

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Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

Medical Research Council (MRC)
EU-Beitrag
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Adresse
20 Park Crescent
W1N 4AL London
Vereinigtes Königreich

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Beteiligte (2)

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Letzte Aktualisierung: 23 Januar 1994

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/EV4V0037/de

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