Objectif OBTAIN COMPLEX ANTIGENS ALLOWING THE DEVELOPMENT OF IMMUNITY AGAINST FOOT AND MOUTH DISEASE VIRUS, AND MAY BE OBTENTION OF A SAFE AND CHEAPER VACCINE AGAINST FOOT AND MOUTH DISEASE. The project aimed at the synthesis in baker's yeast of a hybrid virus like particle comprising the surface antigen of the virus which caused hepatitis B in man, and part of a surface protein from foot and mouth disease virus (FMDV). Many yeast strains were genetically engineered by recombinant deoxyribonucleic acid (DNA) techniques, producing hybrid virus like particles in which the FMDV portion was present at different sites. It is hoped that these studies will shed light on the question of which parts of the FMDV are essential and how they must be presented to the immune system, in order to protect target animals against the disease.THE OBJECTIVE OF THE PROGRAMME IS TO DEVELOP A HIGHLY IMMUNOGENIC COMPLEX CONTAINING FMDV ANTIGENIC DETERMINANTS AGAINST DIFFERENT TYPES OF THE VIRUS.THE POLYVALENT SUB-UNIT VACCINE WILL BE PRODUCED BY RECOMBINANT DNA TECHNIQUES, ASSOCIATING FMVD ANTIGENIC DETERMINANTS WITH HEPATITIS B SURFACE ANTIGENS. THESES RECOMBINANT PARTICLES WILL BE EXPRESSED IN YEAST OR ANIMAL CELLS, AND ANALYSED FOR THEIR IMMUNOLOGICAL PROPERTIES. Champ scientifique natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP1-BAP - Multiannual research action programme (EEC) in the field of biotechnology (BAP), 1985-1989 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Wellcome Foundation Ltd Contribution de l’UE Aucune donnée Adresse Langley Court BR3 3BS Beckenham Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TNO Pays-Bas Contribution de l’UE Aucune donnée Adresse RIJSWIJK Voir sur la carte Coût total Aucune donnée University of Edinburgh Royaume-Uni Contribution de l’UE Aucune donnée Adresse Old College South Bridge EH1 1HN Edinburgh Voir sur la carte Coût total Aucune donnée
