Objective This project is designed to coordinate efforts of thirteen laboratories, from 5 EEC countries, on physical mapping of human chromosome 6. All of these laboratories have an interest either in large scale chromosome mapping or in detailed analysis of a region of the chromosome. Tools will be constructed to enable local short range maps to be integrated into a larger scale map which will be assembled and refined by continued cooperation and consultation between the participants. These tools include radiation-fusion hybrids (RFH), YAC libraries and gridded cosmid libraries from flow sorted chromosome 6. Most of these facilities are already in place. The initial fragmentary physical map will be frequently updated and will be integrated, where possible, with the genetic map. One of the participants (Andreas Ziegler) is responsible for the next chromosome 6 workshop and he will oversee development of the map. On a smaller scale, several of the cooperating groups are involved in investigating key regions of the chromosome. These include: the MHC, where considerable effort is going into locating all of the genes, for haemochromatosis for example, and the sequencing of some regions in their entirety. Another region of interest is 6p23, the location of spinocerebellar ataxia (SCA). At the other end of the chromosome (6q27) there is evidence of a tumour suppressor gene involved in a range of tumours including ovarian cancer. 3 Year Goals: 1) Isolation of all of the genes within the MHC (4Mbp) 2) Complete sequence of the Class II region of the MHC 3) Complete physical map of chromosome 6 Fields of science medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP3-BIOMED 1 - Specific research and technological development programme (EEC) in the field of biomedicine and health, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Imperial Cancer Research Fund (ICRF) EU contribution No data Address 44 Lincoln's Inn Fields WC2A 3PX London United Kingdom See on map Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all Centre National de la Recherche Scientifique France EU contribution No data Address Avenue de Grande Bretagne 31300 Toulouse See on map Total cost No data Centre National de la Recherche Scientifique (CNRS) France EU contribution No data Address 1 avenue Claude Vellefeaux 75475 Paris See on map Total cost No data Christie Hospital NHS Trust United Kingdom EU contribution No data Address Wilmslow Road Didsbury M20 9BX Manchester See on map Total cost No data FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN France EU contribution No data Address Rue Juliette Dodu 27 75010 PARIS See on map Total cost No data HUMBOLDT-UNIVERSITAET BERLIN Germany EU contribution No data Address UNTER DEN LINDEN 9 10099 BERLIN See on map Total cost No data MRC Human Biochemical Genetics Unit United Kingdom EU contribution No data Address 4 Wolfson House Stephenson Way NW1 2HE London See on map Total cost No data NATIONAL RESEARCH COUNCIL OF ITALY Italy EU contribution No data Address Via del Fosso del Cavaliere, 100 00133 ROMA See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address SOUTH PARKS ROAD OX1 3QU OXFORD See on map Total cost No data THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON United Kingdom EU contribution No data Address Brunswick Square 29-39 LONDON See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution No data Address Via della Ricerca Scientifica, 1 Edificio Sogene 00133 ROMA See on map Total cost No data United Medical and Dental Schools of Guy's and St Thomas's United Kingdom EU contribution No data Address St Thomas's Street London Bridge SE1 9RT London See on map Total cost No data Université de Rennes I France EU contribution No data Address 2 avenue du Professeur Léon Bernard 35043 Rennes See on map Total cost No data
