Objectif "All organisms have to cope with changing temperature and various mechanisms have evolved to protect cellular processes against thermal stresses. Many organisms also use temperature signals to align behaviour and development with certain seasons. How specific temperature cues are extracted from fluctuating temperature levels is unknown but it implies the existence of mechanisms that enable long-term monitoring and integration of the enormously variable temperature levels found in nature. We therefore intend to discover how variable temperature levels are measured and integrated over long timescales in order to provide information used in biological timing. Plants provide an excellent system in which to investigate such thermo-sensory mechanisms. We will exploit our knowledge of the multiple regulatory pathways determining quantitative expression of the plant developmental repressor FLOWERING LOCUS C (FLC). These pathways, which are all independently influenced by temperature, converge to regulate FLC via aspects of a co-transcriptional mechanism involving antisense transcripts and different chromatin pathways. This understanding provides the system to define the primary temperature steps (thermo-sensors) that directly regulate FLC and explore how they combine to record complex temperature profiles. Our hypothesis is that different thermo-sensors monitor distinct aspects of the long-term temperature profile. Their outputs would be integrated via accumulation of chromatin modifications at FLC with feedback and interconnection between the pathways providing reinforcement systems to record previous exposure. Modulation of this mechanism would then provide the basis for adaptation to different climates. Knowledge emerging from this study will provide important concepts in understanding how organisms interact with their environment." Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-LS2 - ERC Advanced Grant - Genetics, Genomics, Bioinformatics and Systems Biology Appel à propositions ERC-2013-ADG Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil JOHN INNES CENTRE Contribution de l’UE € 2 403 997,00 Adresse NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Royaume-Uni Voir sur la carte Région East of England East Anglia Breckland and South Norfolk Type d’activité Research Organisations Contact administratif Mary Anderson (Dr.) Chercheur principal Caroline Dean (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire JOHN INNES CENTRE Royaume-Uni Contribution de l’UE € 2 403 997,00 Adresse NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Voir sur la carte Région East of England East Anglia Breckland and South Norfolk Type d’activité Research Organisations Contact administratif Mary Anderson (Dr.) Chercheur principal Caroline Dean (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MITTUNIVERSITETET Suède Contribution de l’UE € 54 000,00 Adresse HOLMGATAN 10 85170 Sundsvall Voir sur la carte Région Norra Sverige Mellersta Norrland Västernorrlands län Type d’activité Higher or Secondary Education Establishments Contact administratif Eva Karlsson (Mrs.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée MAX IV Laboratory, Lund University Suède Contribution de l’UE € 42 000,00 Adresse Paradisgatan 5c 22100 LUND Voir sur la carte Région Södra Sverige Sydsverige Skåne län Type d’activité Higher or Secondary Education Establishments Contact administratif Peter Stenild Matthesen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
