Cel Cancer remains a major health burden worldwide. The aggressive targeting of metabolic pathways shared by normal and cancer cells results in prolonged survival and cures, but at a tremendous cost to patient life quality. What is missing is a therapeutic agent that clearly differentiates normal and cancer cells. This proposal delineates a process for killing exclusively cancer cells with no interference with normal cells. In the past two decades there has been considerable effort to develop attenuated viruses for killing cancer cells. Of the oncolytic viruses in clinical trials, attenuated herpes simplex viruses (HSV) are among the most promising because of safety, affinity for cancer cells, ability to treat patients multiple times without block by adaptive immunity. The shortcoming is that they do not discriminate between normal and cancer cells, are effective in a limited number of patients. The remarkable accomplishment by my laboratory at the basis of the proposal is the genetic engineering of HSVs that specifically infect and kill cancer cells and cannot infect normal cells. The prototype retargeted HSV targets HER2, a receptor in breast, ovary and other tumors. HER2-HSV ablates human breast and ovary cancers, and glioblastoma after intratumoral or intraperitoneal administration.This proposal addresses basic research issues for the advancement of retargeted oncolytic HSVs. It is organized in 5 AIMS• Engineer a non-cancer cell line for virus production acceptable to Health Authorities and re-engineer the retargeted-HSV accordingly. This will enable production of clinical grade retargeted-HSVs for clinical tests (AIM1)• Engineer retargeted-HSVs suitable for systemic delivery and for boosting anti-tumor immunity (AIM2-3)• Apply our platform to expand the repertoire of oncolytic HSVs that target glioblastomas, prostate, head-and-neck, colon carcinomas (AIM4)• Determine the tumorigenic potential of cancer cells that escape killing by retargeted HSVs (AIM5) Dziedzina nauki natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencesinfectious diseasesDNA viruses Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Zaproszenie do składania wniosków ERC-2013-ADG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Wkład UE € 2 347 263,64 Adres VIA ZAMBONI 33 40126 Bologna Włochy Zobacz na mapie Region Nord-Est Emilia-Romagna Bologna Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Maria Gabriella Campadelli (Prof.) Kontakt administracyjny Luisa Romagnoli (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Włochy Wkład UE € 2 347 263,64 Adres VIA ZAMBONI 33 40126 Bologna Zobacz na mapie Region Nord-Est Emilia-Romagna Bologna Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Maria Gabriella Campadelli (Prof.) Kontakt administracyjny Luisa Romagnoli (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI GENOVA Włochy Wkład UE € 123 600,00 Adres VIA BALBI 5 16126 Genova Zobacz na mapie Region Nord-Ovest Liguria Genova Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Loredana Pacetti Merlini (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI VERONA Zakończenie uczestnictwa Włochy Wkład UE € 6 482,36 Adres VIA DELL ARTIGLIERE 8 37129 Verona Zobacz na mapie Region Nord-Est Veneto Verona Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Enrico Cazzaroli (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych