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Adverse Immune Signatures and their Prevention in Corneal Transplantation

Objective

"Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- and partial-thickness procedures performed annually. Adverse immune responses occur in up to 30% of CT recipients causing rejection and failure. The high levels of CT clinical activity and immune complications create an ideal opportunity to comprehensively profile immune responses associated with adverse tissue transplant outcomes and to develop new approaches for their prevention or early diagnosis.
VISICORT is a multi-disciplinary project with expertise in basic immunology, bio-sampling, systems biology/immune profiling, bioinformatics, clinical tissue transplantation and cell therapy. It will complete the first systematic immune profiling of biological samples from animal and human CT recipients with diverse outcomes. Clinical data and bio-specimens from over 700 CT recipients at 5 leading transplant centres will be centrally collated and distributed to cutting-edge university- and SME-based laboratories for multi-platform profiling and integrated bioinformatics analyses. Profiling data will generate better understanding of adverse immune reactions to tissue transplants. This knowledge will be used to develop novel biomarker-based surveillance strategies and, coupled with SME-based expertise in cell product development, will also inform the design and initiation of an optimised clinical trial strategy of immunomodulatory stromal stem cell therapy in high-risk human CT recipients.
VISICORT research will strongly impact multiple EU research/scientific communities, patient cohorts and SMEs and will have high commercialisation value for the biopharmaceutical and biotechnology industries."

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/ophthalmology
  • /medical and health sciences/clinical medicine/transplantation
  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 785 110
Administrative Contact
Prof Matthew Griffin (Prof.)

Participants (11)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 691 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 394 582
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elodie Mahieu-Wedande (Mrs.)
AARHUS UNIVERSITETSHOSPITAL
Denmark
EU contribution
€ 443 582,40
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus
Activity type
Research Organisations
Administrative Contact
Birgit Christensen (Mrs.)
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 394 582
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Prof Conor Murphy (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 714 889,60
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Sophie Brouard (Dr.)
BIOSTOR IRELAND LIMITED
Ireland
EU contribution
€ 512 261,20
Address
Kilrane Business Park
Rosslare Harbour
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Uwe Kuhn (Mr.)
Fios Genomics Limited
United Kingdom
EU contribution
€ 736 604,70
Address
Buchanan Street 166
G1 2LS Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dr Sarah Lynagh (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 653 759,25
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
ORBSEN THERAPEUTICS LIMITED
Ireland
EU contribution
€ 451 320
Address
Unit 1 Galway Business Park
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dr Stephen Elliman (Dr.)
PINTAIL LTD
Ireland
EU contribution
€ 195 000
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 16 800
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Tandskov Dissing (Mr.)