Objective
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, and clinical fields, and combining such interdisciplinary expertise the ACTION consortium will dissect the etiology and pathogenesis of aggression. Based on new insights, ACTION will inform the development of novel diagnostic tools and causative targets and guide the development of treatment and prevention strategies. ACTION is built on interrelated work packages with a focus on a) clinical epidemiology and current classification and treatment problems; b) genetic epidemiology, including Genome Wide Association studies and epigenetics; c) gene-environment correlation and interaction; d) biomarkers and metabolomics. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues. Based on this framework, ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Fields of science
Call for proposal
FP7-HEALTH-2013-INNOVATION-1
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Funding Scheme
CP-FP - Small or medium-scale focused research project
Coordinator
1081 HV Amsterdam
Netherlands
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Participants (11)
2333 ZA Leiden
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QLD 4006 Herston
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17177 Stockholm
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00014 Helsingin Yliopisto
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WC2R 2LS London
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3015 GD Rotterdam
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46556 Notre Dame
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09124 Cagliari
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Participation ended
4102 Seraing
2171 CD Sassenheim
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2311 EZ Leiden
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