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Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology

Objective

Background:
Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptable in relation to the lethal outcome of HH although massively reducing quality of life and also life expectancy.
Aims and objectives:
In order to significantly improve therapy of this awful disorder, we propose to develop a simultaneous imaging/therapy platform allowing diagnostic imaging as well as image guided surgical, photodynamic or radiopeptide therapy to selectively resect/destroy diseased beta cells. This platform will enable delivery of patient-individual tailored therapy, increasing cure rate while significantly reducing or even avoiding side effects. The platform will integrate information from pre-clinical imaging for optimal therapy planning with intra-operative imaging for image guided surgery. By implementation of extended field optical coherence tomography, information on a histopathological level will allow increased precision of therapy. Highly innovative photodynamic therapy will enable selective (endoscopic) destruction of diseased beta cells without resection of pancreatic tissue.
Outcome:
Our highly-innovative integrated imaging/therapy (“theranostic”) platform will allow diagnosis and monitoring of disease, support and guide therapeutic intervention, predict outcome of intervention and individual prognosis. This technology will massively improve therapy, especially in infants, by improving cure rates while significantly reducing morbidity for improved quality of life and increased life expectancy. We will contribute to the goals of the International Rare Diseases Research Consortium (IRDiRC): 200 new therapies.

Field of science

  • /engineering and technology/medical engineering/diagnostic imaging

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 047 000,35
Administrative Contact
Maarten Van Langen (Mr.)

Participants (17)

SURGVISION BV
Netherlands
EU contribution
€ 701 000
Address
Dalhuysenstraat 37
8448 EW Heerenveen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ton Van Den Hoven (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 475 799,65
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna M Van Apeldoorn (Ms.)
PAUL SCHERRER INSTITUT
Switzerland
EU contribution
€ 350 000
Address
Forschungstrasse 111
5232 Villigen Psi
Activity type
Research Organisations
Administrative Contact
Irene Walthert (Mrs.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 350 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 392 588,85
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Thilo Wieczorek (Mr.)
UNIVERSITAET BERN

Participation ended

Switzerland
EU contribution
€ 37 411,15
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emanuel Christ (Prof.)
University College London
United Kingdom
EU contribution
€ 330 058,40
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kamila Kolasinska (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 184 000
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Mrs.)
TURUN YLIOPISTO
Finland
EU contribution
€ 250 000
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mari Riipinen (Dr.)
UNIVERSITE DE LILLE II - DROIT ET SANTE
France
EU contribution
€ 250 000
Address
Rue Paul Duez 42
59800 Lille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Gompel (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 350 000
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Theo Lasser (Prof.)
EXALOS AG
Switzerland
EU contribution
€ 497 000
Address
Wagistrasse 21
8952 Schlieren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marcus Duelk (Dr.)
TransMIT Gesellschaft fuer Technologietransfer mbH
Germany
EU contribution
€ 60 000
Address
Kerkrader Strasse 3
35394 Giessen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Haberland
EANM FORSCHUNGS GMBH
Austria
EU contribution
€ 23 000
Address
Hollandstrasse 14
1020 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henrik Silber (Mr.)
Concentris Research Management GmbH
Germany
EU contribution
€ 340 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Dr.)
piCHEM Forschungs und Entwicklungsgmbh
Austria
EU contribution
€ 312 200
Address
Kahngasse 20
8045 Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Schütz (Mrs.)
GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 49 941,60
Address
Great Ormond Street
WC1N 3JH London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Pratik Shah (Dr.)