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TOR and Cellular Homeostasis

Objective

"The Target Of Rapamycin (TOR) proteins are ser/thr kinases conserved in Eukarya. They nucleate two distinct multiprotein complexes, named TORC1 and TORC2, which regulate many, widely varying, aspects of cell and organism physiology. TOR inhibitors, such as rapamycin and derivatives, are used clinically to treat cancer, cardio-vasculature disease and to prevent organ rejection.

We recently reported that both TORC1/2 are wired in feedback loops, where their downstream cellular effectors are at the same time upstream regulators. It is this feedback loop that ultimately mediates the intrinsic role of TORC1/2 in cellular homeostasis: TORC1/2 detects deviations from a steady-state condition and by means of these feedback loops returns the cell to its homeostatic situation. We propose to systematically identify the TORC1/2 homeostatic signalling loops. Subsequent characterization will focus on the signalling networks controlling intermediary metabolism. Our ultimate goal is to comprehensively unravel the TORC1/2-dependent metabolic networks composed of regulatory feedback loops which will reveal the fundamental role of the TOR Complexes as molecular devices to achieve cellular homeostasis."
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Principal Investigator

Robbie Joseph Loewith (Prof.)

Host institution

UNIVERSITE DE GENEVE

Address

Rue Du General Dufour 24
1211 Geneve

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 991 686

Principal Investigator

Robbie Joseph Loewith (Prof.)

Administrative Contact

Alex Waehry (Dr.)

Beneficiaries (1)

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UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 1 991 686

Project information

Grant agreement ID: 614552

Status

Closed project

  • Start date

    1 April 2014

  • End date

    31 March 2019

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 991 686

  • EU contribution

    € 1 991 686

Hosted by:

UNIVERSITE DE GENEVE

Switzerland