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A Photo-triggered On-demand Drug Delivery System for Chronic Pain

Objetivo

"Nerve pain affects millions of people, and can be personally devastating for people who experience it. Current methods for pain management (e.g. local injection of pain killers) are inadequate because of the short duration of action. Even sustained release treatments, such as drug-loaded liposomes, provide only one week of analgesia producing a continuous extended nerve blockade without allowing for changes in daily physical activity or level of pain relief. More importantly, such systems cannot be turned off until they run their course.

In this proposal, a locally-injected or implanted near infrared (NIR)-sensitive drug reservoir that can be triggered by a simple handheld laser device applied externally is described. The device enables drug release with consistent response over multiple on/off cycles. Such a device, implanted (or eventually injected) on a nerve or near the neuraxis, could have substantial clinical impact in the treatment of chronic (or prolonged perioperative) pain.

This system will consist of an impermeable ethylcellulose membrane embedded with temperature-sensitive polymer nanoparticles and NIR-active gold nanoparticles. The membrane will be engineered such that the nanoparticles form a disordered but interconnected network throughout. The gold nanoparticle concentration will be adjusted so that light-induced heating of the nanoparticles produces sufficient heat to collapse the polymer, thus opening the porous network. Those nanostructured materials which compose the device will be produced in a continuous manner by using microfluidic reactors to avoid the characteristic disadvantages when using conventional discontinuous (batch) reactors. Nanoparticle-synthesis protocols will be supported by computational fluid dynamics.

The specific aims will be geared toward engineering a NIR-triggered drug release device and optimizing for a variety of drug types, then demonstrating its biocompatibility and therapeutic effectiveness in vivo."

Ámbito científico

  • /ciencias naturales/ciencias químicas/química inorgánica/compuestos inorgánicos
  • /ciencias naturales/ciencias físicas/mecánica clásica/mecánica de fluidos/dinámica de fluidos
  • /ingeniería y tecnología/nanotecnología/nanomateriales
  • /ciencias naturales/ciencias físicas/óptica/física del láser

Convocatoria de propuestas

ERC-2013-CoG
Consulte otros proyectos de esta convocatoria

Régimen de financiación

ERC-CG - ERC Consolidator Grants

Institución de acogida

UNIVERSIDAD DE ZARAGOZA
Dirección
Calle Pedro Cerbuna 12
50009 Zaragoza
España
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 570 091
Investigador principal
Manuel Arruebo Gordo (Dr.)
Contacto administrativo
Carmen Baras (Ms.)

Beneficiarios (1)

UNIVERSIDAD DE ZARAGOZA
España
Aportación de la UE
€ 1 570 091
Dirección
Calle Pedro Cerbuna 12
50009 Zaragoza
Tipo de actividad
Higher or Secondary Education Establishments
Investigador principal
Manuel Arruebo Gordo (Dr.)
Contacto administrativo
Carmen Baras (Ms.)