Periodic Report Summary 2 - MYELOSHOCK (Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples)
Allergic shock (anaphylaxis) is a life-threatening reaction to allergens (food, drugs, pollens, venom, etc) occurring in individuals that produce particular antibodies against these allergens. Project MyeloSHOCK aims at unraveling the parameters that control anaphylaxis using novel mouse models closer to the human physiology, strengthened by human-based studies involved patients undergoing anaphylaxis. Halfway through the project we have already identified several pathways leading to disease induction depending on the type of antibodies that can bind the allergen. We have identified the predominant antibody receptors involved in anaphylaxis induction and severity in normal mice, but also in mice expressing human antibody receptors (as a correlate to human anaphylaxis), and could exclude antibody receptors that cannot participate in this reaction. Through these analyses in mouse models and analyses using human samples, we propose that a particular subset of blood cells are responsible for anaphylaxis that were not considered before. These data suggest novel treatment possibilities for this life threating reaction that has neither specific treatment nor cure.