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Dark matter of the human transcriptome: Functional study of the antisense Long Noncoding RNAs and Molecular Mechanisms of Action

Periodic Report Summary 2 - DARK (Dark matter of the human transcriptome: Functional study of the antisense Long Noncoding RNAs and Molecular Mechanisms of Action)

This proposal sets out to tackle the central questions about the dark side of our genome, representing more thatn 98% of the genome and that remain largely unknown. In particular, we propose to identify an unidentified set of genes non-coding for protein and embedded antisense to other genes. By using a variety of complementary high standard deep sequencing approaches, we aim to characterize novel species of human hidden RNA that might have fundamental functions for the genome integrity especially in cancer cells. . Based on our international recognized expertise and supported by strong preliminary results, we believed that the accomplishment of this project will nucleate major leaderships in Europe on human antisense lncRNAs.