Objetivo Melanoma is the most aggressive form of skin cancer and one of the most invasive tumor types. Melanoma incidence keeps increasing worldwide and the therapeutic choices are limited. The lack of treatments with durable responses may be due, at least in part, to an incomplete understanding of the molecular mechanisms that regulate tumor initiation and/or progression to metastasis. Therefore, there is an urgent need to find new strategies to expand our knowledge of melanomagenesis.We propose a new approach to unravel the complexity of melanoma: To use a cellular differentiation model to decipher the role of epigenetic regulation during melanocyte differentiation and its contribution to melanoma progression. Melanoma cells often express developmental genes, display multi-differentiation potential, and seem to recapitulate the migratory nature of neural crest stem cells from which melanocytes arise. We reasoned that studying a model of differentiation of melanocytes from neural crest stem cells could be useful to identify the mechanisms that modulate melanoma stem-like properties, probably among the most significant contributing features to the tumor aggressiveness. The plasticity and reversibility of the epigenetic mechanisms make them ideal orchestrators of these dynamic processes. Then, we hypothesize that epigenetically controlled miRNAs could be involved in normal differentiation and in tumorigenesis when altered. Thus, aberrant epigenetic modifications could be responsible for reactivation (or retention) of stem-like properties in melanoma cells. The identification of epigenetically regulated miRNAs involved in melanoma progression will be useful not only as prognosis biomarkers in order to stratify patients for more rigorous follow-up and aggressive therapy, but also by their potential as therapeutic targets considering the reversibility of epigenetic changes. Ámbito científico medical and health sciencesclinical medicineoncologyskin cancermelanomamedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsepigenetics Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Convocatoria de propuestas FP7-PEOPLE-2013-IOF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IOF - International Outgoing Fellowships (IOF) Coordinador FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Aportación de la UE € 352 176,30 Dirección AVENIDA GRAN VIA HOSPITALET 199-203 08908 L'Hospitalet De Llobregat España Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Research Organisations Contacto administrativo Helena Diaz (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
