Objetivo "Motivational control is crucial for adaptive behaviors. Conversely, disruption of motivational control leads to maladaptive behaviors and is one of the core symptoms of addiction. Noradrenaline (NA) system, encompassing NA neurons in locus coeruleus and nucleus tractus solitiarius is well positioned to regulate motivational control; however its exact contribution is not fully understood. Here we aim to evaluate the role of NA system activity in the ventral tegmental area (VTA) in motivational control in both opiate-naive and opiate-exposed mice. Using behavioral model of motivational control in combination with real-time, dynamic optical stimulation of NA neurons terminals in the VTA we plan to provide unprecedented data on NA mechanisms of motivational control and identify specific brain locus within the NA system responsible for specific type of motivational control. In addition, proposed project aims at transfering optogenetics ""know how"" to the host Institution." Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships" Convocatoria de propuestas FP7-PEOPLE-2013-IIF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IIF - International Incoming Fellowships (IIF) Coordinador INSTYTUT FARMAKOLOGII IM. JERZEGO MAJA POLSKIEJ AKADEMII NAUK Aportación de la UE € 140 863,80 Dirección UL. SMETNA 12 31 343 Krakow Polonia Ver en el mapa Región Makroregion południowy Małopolskie Miasto Kraków Tipo de actividad Research Organisations Contacto administrativo Ryszard Przewlocki (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
