Objectif Cardiovascular disease (CVD) remains the leading cause of death within the European Union and new, more effective forms of treatment are urgently needed. Recent studies have shown that patients with low plasma homoarginine are at increased risk of stroke, myocardial infarction and heart failure (HF). This project aims to explore the underlying mechanisms of this association and to determine the therapeutic potential of homoarginine supplementation. We have already shown that mice with homoarginine-deficiency exhibit increased brain injury following an experimental stroke, and further, that elevating homoarginine levels is protective in normal mice. We hypothesize that homoarginine is more a mediator than a mere biomarker for positive outcome in CVD. Specifically, we propose that increased homoarginine in mice will also be beneficial in experimental models of acute ischaemia and chronic HF. Our objectives are, 1) to study whether low homoarginine levels are detrimental in the ischaemic and failing heart and demonstrate rescue by homoarginine treatment; 2) to determine whether homoarginine supplementation is beneficial; and 3) to elucidate the mechanism for how homoarginine exerts its cardiac effects. This interdisciplinary project brings together the applicant’s (Germany) specific expertise in pharmacology and detailed knowledge of the homoarginine research field, with the opportunity to receive extensive in vivo training in an array of cutting-edge murine cardiac phenotyping techniques developed by the scientist in charge (UK). For example, LV catheterization, in vivo MRI, echocardiography, 31P-NMR and surgical models of ischaemia and HF in mice. In conclusion, by extensive training of the Fellow, this project will 1) pave the road to develop scientific independence, 2) foster intra-European collaboration, 3) provide a basis for further funding, and 4) give novel insights into CVD pathophysiology to the scientific community and to the general public. Champ scientifique medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicineneurologystrokemedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contribution de l’UE € 221 606,40 Adresse WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Royaume-Uni Voir sur la carte Région South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Type d’activité Higher or Secondary Education Establishments Contact administratif Gill Wells (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée