Objective Calyciphylline K is a Daphnezomine L-type natural product with promising anticancer activity. We propose to complete the total synthesis of Calyciphylline K and several closely-related Daphnezomine L alkaloids by developing a novel asymmetric organocatalytic Malononitrile Michael Addition methodology to facilitate their preparation in a short sequence of around 12 synthetic steps. The anticancer activity of Calyciphylline K and other analogues prepared during this study will then be evaluated using Alamar Blue cell viability assays, followed by further study in collaboration with the Structural Genomics Consortium (SGC), where high-throughput kinase screening assays are available to further understand their pharmacological mode of action. This project will provide significant advances in the field of organocatalysis (new methodology for asymmetric synthesis), natural product synthesis (first preparation of the Daphnezomine L alkaloids) and anticancer medicinal chemistry and pharmacology (exploration and study of biological activities). Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicinemedicinal chemistrymedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2013-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD EU contribution € 221 606,40 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
