Cel Oxidation is one of the central reaction classes in organic chemistry and significant progress has been made in the development of reagents that are capable of oxidising complex molecules with high levels of selectivity. However, much remains to be achieved, and synthetic chemistry is not yet close to the levels of selectivity and efficiency that are achieved by enzymes. The use of small organic molecules to promote chemical reactions is an extremely competitive and timely area in which to work, with an increasing movement from the chemical and pharmaceutical industry towards more sustainable technologies.M-FOOS is a proposal focused on the development of new carbon-based and metal-free oxidising agents to radically change the way that key oxidative transformations are accomplished, making them more powerful and user-friendly. We expect this project to have a significant international impact within organic chemistry in general, including the adoption of our chemistry in academia and the pharmaceutical and chemical industries. The project proposes to develop an approach using o-quinones and iminoquinones as new reagents to accomplish the syn selective (stereospecific) oxidation of alkenes.Collaboration involving synthetic electrochemistry with a world-leading electrochemist, Prof. R. G. Compton (Department of Chemistry at Oxford), will be established to understand and improve the oxidising properties of the o-quinones. Using molecular modelling, in collaboration with an expert (Dr. R. Paton, University of Oxford), we should be able to understand the process and optimise to an excellent candidate for our oxidant system. As 1,2-diamines are present in biologically active natural products, it will also be very fruitful to prepare and then test the biological activity of these diamine containing compounds under an established collaboration with Dr. A. Russell (Pharmacology, University of Oxford). Dziedzina nauki natural scienceschemical sciencesorganic chemistrymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical scienceselectrochemistryelectrolysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Wkład UE € 221 606,40 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Gill Wells (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych