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Towards Biodegradable Nanoparticles: Hybrid Organic Mesoporous Silica

Objective

Despite their great potential, full exploitation of mesoporous silica nanoparticles (MSiNPs) as in-vivo multi-functional theranostic agents is still held back by the lack of a controlled and complete biodegradability. Indeed removal of nano-medical tools from the biologic system after the accomplishment of their diagnostic or therapeutic function still remains a pivotal, yet unresolved issue impeding their clinical translation. A most desirable design for improving the properties of nano-medical tools would hence involve their ability to hierarchically self-degrade into renally clearable products after carrying out their function. Thus, the ambitious aim of this project targets the synthesis of novel, specific, hybrid MSiNPs-based theranostic tools, able to perform their beneficial action and subsequently fragment in smaller pieces allowing easy execration via renal system. In this way, thanks to the combination of the intrinsic biocompatibility of MSiNPs, their ease of functionalization and the newly conferred enhanced biodegradability, a superior material adaptable to a wide range of diagnostic and therapeutic applications, with great promise for clinical translation, will be achieved.
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Coordinator

UNIVERSITE DE STRASBOURG

Address

Rue Blaise Pascal 4
67081 Strasbourg

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 97 023,30

Administrative Contact

Sandrine Schott-Carrière (Mrs.)

Project information

Grant agreement ID: 627788

Status

Closed project

  • Start date

    1 March 2014

  • End date

    28 February 2015

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 97 023,30

  • EU contribution

    € 97 023,30

Coordinated by:

UNIVERSITE DE STRASBOURG

France