Objectif An outstanding question in Neuroscience is to understand how the brain integrates sensory and non-sensory information. Strikingly, this integration takes place even in the primary sensory cortices, where sensory processing is strongly modulated by non-sensory context. For example, in primary visual cortex (V1), responses depend not only on visual stimulation, but also on locomotion (Niell and Stryker 2010, Neuron 65). Specifically, locomotion controls the spatial integration of V1 neurons, reducing the suppression they receive from the surround of their receptive fields (Ayaz, et al. 2013, Curr Biol 23). I will investigate the neural mechanisms underlying this phenomenon. My working hypothesis is that different classes of cortical interneurons contribute in a very specific manner to surround suppression and to modulation by locomotion. I will test this through a combination of experiment and computational modeling. First, I will measure how the different neural classes are activated for different stimulus sizes during rest and running. I will use 2-photon imaging to record the calcium activity of neurons in the superficial layers of V1 in mouse lines where I can simultaneously identify the classes of the interneurons thanks to a red fluorescent protein. Second, I will summarize these measures with a neural network model in which the different classes of neurons will be described by different variables, to match the experimental data. The circuits and computations uncovered by this project are likely to generalize to other areas of the cerebral cortex, and therefore to constitute fundamental organizational principles for cortical integration of internal and external inputs. Champ scientifique natural sciencesbiological sciencesneurobiologynatural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSITY COLLEGE LONDON Contribution de l’UE € 221 606,40 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Malgorzata Kielbasa (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
