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Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease: the PREDIMED PLUS Study

Información del proyecto

Identificador del acuerdo de subvención: 340918

Estado

Proyecto cerrado

  • Fecha de inicio

    1 Mayo 2014

  • Fecha de finalización

    30 Abril 2019

Financiado con arreglo a:

FP7-IDEAS-ERC

  • Presupuesto general:

    € 2 078 969,62

  • Aportación de la UE

    € 2 078 969,62

Organizado por:

UNIVERSIDAD DE NAVARRA

España

Objetivo

The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial.
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Investigador principal

Miguel ángel Martínez González (Prof.)

Institución de acogida

UNIVERSIDAD DE NAVARRA

Dirección

Campus Universitario Edificio Central
31080 Pamplona

España

Tipo de actividad

Higher or Secondary Education Establishments

Aportación de la UE

€ 1 496 754,47

Investigador principal

Miguel ángel Martínez González (Prof.)

Contacto administrativo

Fco. Javier Irigoyen Barrio (Mr.)

Beneficiarios (2)

UNIVERSIDAD DE NAVARRA

España

Aportación de la UE

€ 1 496 754,47

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

España

Aportación de la UE

€ 582 215,15

Información del proyecto

Identificador del acuerdo de subvención: 340918

Estado

Proyecto cerrado

  • Fecha de inicio

    1 Mayo 2014

  • Fecha de finalización

    30 Abril 2019

Financiado con arreglo a:

FP7-IDEAS-ERC

  • Presupuesto general:

    € 2 078 969,62

  • Aportación de la UE

    € 2 078 969,62

Organizado por:

UNIVERSIDAD DE NAVARRA

España