Cel The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial. Dziedzina nauki social sciencessociologydemographymortalityengineering and technologymaterials engineeringcompositesmedical and health scienceshealth sciencesnutritionmedical and health sciencesclinical medicinecardiologycardiovascular diseases Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Zaproszenie do składania wniosków ERC-2013-ADG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca UNIVERSIDAD DE NAVARRA Wkład UE € 1 496 754,47 Adres CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona Hiszpania Zobacz na mapie Region Noreste Comunidad Foral de Navarra Navarra Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Miguel ángel Martínez González (Prof.) Kontakt administracyjny Fco. Javier Irigoyen Barrio (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSIDAD DE NAVARRA Hiszpania Wkład UE € 1 496 754,47 Adres CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona Zobacz na mapie Region Noreste Comunidad Foral de Navarra Navarra Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Miguel ángel Martínez González (Prof.) Kontakt administracyjny Fco. Javier Irigoyen Barrio (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. Hiszpania Wkład UE € 582 215,15 Adres CALLE MONFORTE DE LEMOS 5 28029 Madrid Zobacz na mapie Region Comunidad de Madrid Comunidad de Madrid Madrid Rodzaj działalności Research Organisations Kontakt administracyjny Manuel Sanchez (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych