Objectif In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children.Different therapeutic interventions for male infertility have to be developed depending on the severity of germ cell deficits in individual patients. In cases where undifferentiated germ cells are present in the testis, strategies based on sperm development from spermatogonial stem cells (SSCs) in vitro or in vivo need to be established. However, if no germ cells are present in the testis, somatic cells of such patients will be the only option from which to develop their own sperm. Development of these potential therapies requires detailed understanding of the entire process of sperm production from stem cells through to functional sperm. This information is still incomplete and fragmented.The current proposal seeks to train young scientists in a network that joins together the complementary knowledge and expertise of several public and private EU partners from disciplines of physiology, cell biology, molecular biology, chemistry and medicine in the field of male reproduction to investigate three strategies for sperm development: (1) propagation of human SSCs in vitro followed by their transplantation, (2) sperm development in vitro from stem cells or early germ cells, (3) sperm development in human testis tissue grafts in vivo.By coaching young scientists in this inter-sectorial and multidisciplinary network, we will train the next generation of researchers within the EU who are then primed to become leaders in the field of male fertility that continue to investigate basic science and translational aspects leading to novel interventions and clinical applications. Champ scientifique medical and health sciencesclinical medicineandrologysocial sciencessociologydemographyfertilitymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicinetransplantation Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks" Appel à propositions FP7-PEOPLE-2013-ITN Voir d’autres projets de cet appel Régime de financement MC-ITN - Networks for Initial Training (ITN) Coordinateur ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Contribution de l’UE € 682 722,92 Adresse MEIBERGDREEF 15 1105AZ Amsterdam Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Contact administratif Eugenie Quartier (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire VRIJE UNIVERSITEIT BRUSSEL Belgique Contribution de l’UE € 576 035,52 Adresse PLEINLAAN 2 1050 Bruxelles / Brussel Voir sur la carte Région Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Type d’activité Higher or Secondary Education Establishments Contact administratif Nik Claesen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Pays-Bas Contribution de l’UE € 204 856,75 Adresse KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Research Organisations Contact administratif Don Van Velzen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAET MUENSTER Allemagne Contribution de l’UE € 444 137,76 Adresse SCHLOSSPLATZ 2 48149 MUENSTER Voir sur la carte Région Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Hanna Becker Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée KAROLINSKA INSTITUTET Suède Contribution de l’UE € 519 850,32 Adresse Nobels Vag 5 17177 Stockholm Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Higher or Secondary Education Establishments Contact administratif Olle Söder (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF EDINBURGH Royaume-Uni Contribution de l’UE € 285 056,64 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Rod Mitchell (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée LEAD PHARMA HOLDING BV Pays-Bas Contribution de l’UE € 236 861,46 Adresse KLOOSTERSTRAAT 9 5349 AB OSS Voir sur la carte Région Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Silvy Van Tuijl (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée