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Global Dynamics of Proteolytic Quality Control Networks in Stress Response and Aging

Periodic Report Summary 2 - PROTEODYNAMICS (Global Dynamics of Proteolytic Quality Control Networks in Stress Response and Aging)

The PROTEODYNAMICS project aims to unravel the mechanisms through which the proteome is maintained during stress and aging. We are interested in how response mechanisms to proteotoxic conditions accelerate the aging process and age-related protein aggregation in Alzheimer’s and Parkinson’s patients. In the PROTEODYNAMICS project we have employed the powerful genetic model of Caenorhabditis elegans as multicellular organism to study how different protein degradation pathways are mechanistically coordinated during animal development and aging. We have uncovered a conserved coordination between longevity assurance mechanisms that maintain tissue-specific functions and the response to proteostasis defects accumulation with age. Moreover, we identified novel non-cell-autonomous signaling pathways that allow cross communication between different tissues to adapt to age-related increase of protein damage.