Obiettivo Cancer is a major health problem due to the failure of current therapies to effectively eradicate the disease. Alternative signaling pathways compensate for a therapeutically targeted pathway, a process referred to as 'evasive resistance'. The identities of the alternative signaling pathways and functional interconnections that underlie evasive resistance remain widely unknown. We propose to integrate cutting-edge clinical, molecular, and computational sciences to understand the signaling defects that allow tumors to evade therapy. With its synergistic, interdisciplinary approach, the proposed project is, to our knowledge, unique in Europe and possibly worldwide.Within the framework of rigorously designed clinical studies, a clinician will provide basic research scientists with diseased tissue isolated before therapy, during treatment or at the time of tumor progression. The tissue, chosen based on medical importance, accessibility to repeated sampling, and ethical considerations, will be from hepatocellular carcinoma. Tumor tissue will be obtained by needle biopsy and snap frozen to preserve in vivo properties. The basic research scientists and a computational biologist will determine, characterize and model the underlying signaling defects. Importantly, using longitudinal clinical samples in combination with mouse and cellular HCC model systems, we will seek to define treatment-related changes in cell signaling that allow tumors to circumvent therapy. This process will be iterative such that changes in treatment strategies will again be monitored in the same patient or experimental model. Insights gained will be used (i) to understand mechanisms of evasive resistance, (ii) to identify novel drug targets and predictive biomarkers, and (iii) to rationally design personalized medicine that ultimately increases therapeutic effectiveness and reduces financial burden. This innovative, comprehensive endeavor will improve diagnosis, treatment and clinical outcome. Campo scientifico natural sciencesbiological sciencescell biologycell signalingnatural sciencescomputer and information sciencescomputational sciencemedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencespersonalized medicine Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-2013-SyG - ERC Synergy Grant Invito a presentare proposte ERC-2013-SyG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SyG - Synergy grant Primo ricercatore principale Michael N. Hall Prof. Istituzione ospitante UNIVERSITAT BASEL Contributo UE € 5 491 133,20 Indirizzo PETERSPLATZ 1 4051 Basel Svizzera Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Michael N. Hall (Prof.) Contatto amministrativo Kurt Kamber (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITAT BASEL Svizzera Contributo UE € 5 491 133,20 Indirizzo PETERSPLATZ 1 4051 Basel Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Michael N. Hall (Prof.) Contatto amministrativo Kurt Kamber (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Svizzera Contributo UE € 3 026 778,00 Indirizzo Raemistrasse 101 8092 Zuerich Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Niko Beerenwinkel (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITATSSPITAL BASEL Svizzera Contributo UE € 2 679 970,80 Indirizzo HEBELSTRASSE 32 4031 Basel Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contatto amministrativo Markus Heim (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
