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Micro Gradient Polyacrylamide Gels for High Throughput Electrophoresis Analysis

Ziel

Polyacrylamide gel electrophoresis (PAGE) is the most widespread tool to separate and detect macromolecules based on their molecular weight. New generation PAGE assays miniaturize the technique to obtain high throughput performance and reduce sample volume, reagents and cost. Here, we present a novel technology that will improve the range, the resolution and the accuracy that these new generation PAGE assays can resolve. On traditional PAGE assays, polyacrylamide gels with an acrylamide gradient are used to significantly improve the separation of macromolecules. However, on new generation PAGE assays the technology to fabricate those gradients at the millimetre scale with micron resolution is missing. The technology presented in this project, developed as a part of the ERC project GenesForceMotion, allows the fabrication of millimetre sized polyacrylamide gels with a well-defined and precise acrylamide microgradient. Moreover, the acrylamide density profile can be precisely controlled along the gel to improve the separation of macromolecules with similar molecular weights. This technology generates a market opportunity to improve the performance of the gel electrophoresis technique widely extended in worldwide life science laboratories. The expected outcome of the project is to test the benefits of our microgradient gel technology to improve the new generation miniaturized PAGE assays and make this technology available to the market

Aufforderung zur Vorschlagseinreichung

ERC-2013-PoC
Andere Projekte für diesen Aufruf anzeigen

Gastgebende Einrichtung

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
EU-Beitrag
€ 148 962,65
Adresse
CARRER BALDIRI REIXAC PLANTA 2A 10-12
08028 Barcelona
Spanien

Auf der Karte ansehen

Region
Este Cataluña Barcelona
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Josep Samitier (Prof.)
Links
Gesamtkosten
Keine Daten

Begünstigte (1)