Objetivo "Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral unit at the neuronal level. Using a differential reinforcement procedure where mice learn to chunk rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. Besides activity signaling sequence initiation (start), we found neurons with sustained or inhibited activity throughout the execution of an entire sequence. These findings clearly show that basal ganglia circuits display neural activity related to the execution of whole action sequences, rather than unitary elements. Neurons with start, sustained and inhibited sequence-related activity were observed throughout the basal ganglia, namely in the main input (striatum), and output (substantia nigra reticulata) nuclei of the basal ganglia. However, the basal ganglia have different cell types/subcircuits linking input to output, the so called direct ves. indirect pathways. Furthermore, basal ganglia output projects to different target areas. Here we will 1) determine if these correlates of motor concatenation are differentially expressed in direct versus indirect basal ganglia pathways by optogenetic identification of cell types in the striatum and in vivo imaging, 2) test the necessity and sufficiency of these two pathways in action sequence initiation and performance, and 3) test if different basal ganglia output circuits express and mediate different aspects of action chunking. These experiments will dissect with unprecedented spatial and temporal precision the role of basal ganglia subcircuits in the initiation and performance of action chunks." Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-CG-2013-LS5 - ERC Consolidator Grant - Neurosciences and Neural Disorders Convocatoria de propuestas ERC-2013-CoG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-CG - ERC Consolidator Grants Institución de acogida FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Aportación de la UE € 1 998 600,00 Dirección AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD 1400-038 Lisboa Portugal Ver en el mapa Región Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo de actividad Research Organisations Contacto administrativo Tania Vinagre (Dr.) Investigador principal Rui Manuel Marques Fernandes Da Costa (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Portugal Aportación de la UE € 1 998 600,00 Dirección AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD 1400-038 Lisboa Ver en el mapa Región Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo de actividad Research Organisations Contacto administrativo Tania Vinagre (Dr.) Investigador principal Rui Manuel Marques Fernandes Da Costa (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos