CORDIS
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CORDIS

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Phylogeography and somatic evolution of cancer tumor cells

Project information

Grant agreement ID: 617457

Status

Closed project

  • Start date

    1 October 2014

  • End date

    30 September 2019

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 999 899,60

  • EU contribution

    € 1 999 899,60

Hosted by:

UNIVERSIDAD DE VIGO

Spain

Objective

"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of somatic evolution. The evolution of cancer tumors in a body can be likened with the evolution of populations in more or less fragmented habitats. The tumor is usually a expanding population of clonal cells, which may differentiate to a bigger or lesser extent (population structure) and disperse to contiguous (range expansion) or more distant tissues (long distance colonization). During tumor progression, this population of cells is subject to distinct somatic evolutionary processes like mutation, drift, selection or migration, which can act at different points in time and geographical space. Very recently, the discovery of extensive intratumor heterogeneity, together with the rise of single cell genomics, has created an unique opportunity to study the phylogeography of cancer tumor cells. So far evolutionary inferences drawn from cancer genomes have been mostly qualitative. Here we propose to study a thousand single cell genomes from different regions in primary tumors and matched metastases. We will develop and apply state-of-the-art statistical and computational techniques from phylogenetics, phylogeography and population genomics to understand the tempo and mode of evolution of cell lineages within and between cancer tumors. By doing so we aim to construct a robust theoretical and methodological evolutionary framework that can contribute to a better understanding of the process of somatic evolution and shed light into the biology of cancer."
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Principal Investigator

David Posada Gonzalez (Prof.)

Host institution

UNIVERSIDAD DE VIGO

Address

Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 201 045,60

Principal Investigator

David Posada Gonzalez (Prof.)

Administrative Contact

Anxo Moreira González (Mr.)

Beneficiaries (4)

UNIVERSIDAD DE VIGO

Spain

EU Contribution

€ 1 201 045,60

FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA

Spain

EU Contribution

€ 478 850

FUNDACIO PARC CIENTIFIC DE BARCELONA

Spain

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 320 004

Project information

Grant agreement ID: 617457

Status

Closed project

  • Start date

    1 October 2014

  • End date

    30 September 2019

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 999 899,60

  • EU contribution

    € 1 999 899,60

Hosted by:

UNIVERSIDAD DE VIGO

Spain