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Phylogeography and somatic evolution of cancer tumor cells

Objective

"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of somatic evolution. The evolution of cancer tumors in a body can be likened with the evolution of populations in more or less fragmented habitats. The tumor is usually a expanding population of clonal cells, which may differentiate to a bigger or lesser extent (population structure) and disperse to contiguous (range expansion) or more distant tissues (long distance colonization). During tumor progression, this population of cells is subject to distinct somatic evolutionary processes like mutation, drift, selection or migration, which can act at different points in time and geographical space. Very recently, the discovery of extensive intratumor heterogeneity, together with the rise of single cell genomics, has created an unique opportunity to study the phylogeography of cancer tumor cells. So far evolutionary inferences drawn from cancer genomes have been mostly qualitative. Here we propose to study a thousand single cell genomes from different regions in primary tumors and matched metastases. We will develop and apply state-of-the-art statistical and computational techniques from phylogenetics, phylogeography and population genomics to understand the tempo and mode of evolution of cell lineages within and between cancer tumors. By doing so we aim to construct a robust theoretical and methodological evolutionary framework that can contribute to a better understanding of the process of somatic evolution and shed light into the biology of cancer."

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

ERC-2013-CoG
See other projects for this call

Funding Scheme

ERC-CG - ERC Consolidator Grants

Host institution

UNIVERSIDAD DE VIGO
Address
Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 201 045,60
Principal investigator
David Posada Gonzalez (Prof.)
Administrative Contact
Anxo Moreira González (Mr.)

Beneficiaries (4)

UNIVERSIDAD DE VIGO
Spain
EU contribution
€ 1 201 045,60
Address
Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra
Activity type
Higher or Secondary Education Establishments
Principal investigator
David Posada Gonzalez (Prof.)
Administrative Contact
Anxo Moreira González (Mr.)
FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA
Spain
EU contribution
€ 478 850
Address
Hospital Clínico Universitario. Edif. Consultas Planta -2. Choupana S/n
15706 Santiago De Compostela
Activity type
Research Organisations
Administrative Contact
Esther Sande (Ms.)
FUNDACIO PARC CIENTIFIC DE BARCELONA

Participation ended

Spain
Address
Baldiri I Reixac 4
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Marta Molina Gómez (Ms.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 320 004
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Pedro Corral (Mr.)