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The chemical biology of RNA G-quadruplexes

Objective

"For over a decade, our research programme has focused on the chemical biology of nucleic acids. The structure of nucleic acids is key to their biological functions, and the four-stranded guanine rich class of structures called G-quadruplexes constitute a particularly intriguing motif. Recent evidence suggests a role for G-quadruplex (G4) structures in RNA leaving their fundamental importance in biology open for exploration. Our central hypothesis is that the G4 structural motif, rather than its sequence per se, conveys important function(s) in RNA. We propose to directly address this hypothesis by the experimental identification of functional RNA G4 structures within the cellular transcriptome on a genome-wide scale. In particular, we intend to reveal detailed insights into their functional contributions to: a) translation and b) telomere biology. The proposed programme constitutes an integrated, interdisciplinary approach that combines chemical biology, synthetic chemistry, molecular and cell biology together with genomics."

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid

Call for proposal

ERC-2013-ADG
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 499 107
Principal investigator
Shankar Balasubramanian (Prof.)
Administrative Contact
Renata Schaeffer (Ms.)

Beneficiaries (1)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 2 499 107
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Principal investigator
Shankar Balasubramanian (Prof.)
Administrative Contact
Renata Schaeffer (Ms.)