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EuroMix

EuroMix

Objective

Euromix aim to develop an experimentally verified, tiered strategy for the risk assessment of mixtures of multiple chemicals derived from multiple sources across different life stages. The project takes account of the gender dimension and balances the risk of chemicals present in foods against the benefits of those foods.
Important concepts for this new strategy are prioritisation criteria for chemicals based on their exposure and hazard characteristics and evaluation of the role of mode of action in grouping chemicals into cumulative assessment groups. In-silico and in-vitro tools will be developed and verified against in-vivo experiments, with focus on four selected endpoints (liver, hormones, development and immunology) to provide a full proof-of-principle. The EuroMix project will result in an innovative platform of bioassays for mixture testing and refined categorisation of chemicals in cumulative assessment groups.
New hazard and exposure models will be embedded in a model toolbox, made available for stakeholders through an openly accessible web-based platform. Access to the web-based tools will be facilitated by training. Criteria will be set and guidance will be written on how to use and implement the tiered test strategy. Dissemination and harmonisation of the approach within EU, Codex Alimentarius, and WHO will be achieved by involving a.o. WHO and US-EPA in the project and by the participation of experts playing a key role in helping establish international food safety policies.
It is expected that the new mechanism-based strategy, the bioassay platform, the openly accessible web-based model toolbox, and clear guidance on a tiered hazard and exposure test and risk assessment strategy will boost innovation in the public and private sector, provide a sound scientific basis for managing risks to public health from chemical mixtures, ultimately reduce the use of laboratory animals, and support the global discussion of risk assessment policies for mixtures.

Coordinator

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Address

Antonie Van Leeuwenhoeklaan 9
3721 Ma Bilthoven

Netherlands

Activity type

Research Organisations

EU Contribution

€ 1 024 699,68

Participants (22)

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STICHTING WAGENINGEN RESEARCH

Netherlands

EU Contribution

€ 1 186 874

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 297 500

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL

France

EU Contribution

€ 449 286

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

EU Contribution

€ 348 341

INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS

France

EU Contribution

€ 298 144

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 348 958

EUROPEAN FRESH PRODUCE ASSOCIATION AISBL

Belgium

EU Contribution

€ 48 750

BUNDESINSTITUT FUER RISIKOBEWERTUNG

Germany

EU Contribution

€ 797 875

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 484 702

MATIS OHF

Iceland

EU Contribution

€ 313 681

Ministry of Health of the Republic of Cyprus

Cyprus

EU Contribution

€ 50 000

NACIONALNI INSTITUT ZA JAVNO ZDRAVJE

Slovenia

EU Contribution

€ 50 313

STATNI ZDRAVOTNI USTAV

Czechia

EU Contribution

€ 75 093

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 497 738

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 425 720

BENAKI PHYTOPATHOLOGICAL INSTITUTE

Greece

EU Contribution

€ 249 633

UNIVERSITA DEGLI STUDI DI MILANO

Italy

EU Contribution

€ 592 538,81

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 74 982

HEALTH AND SAFETY EXECUTIVE

United Kingdom

EU Contribution

€ 13 229,16

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

United Kingdom

FERA SCIENCE LIMITED

United Kingdom

EU Contribution

€ 371 039,35

Project information

Grant agreement ID: 633172

Status

Closed project

  • Start date

    15 May 2015

  • End date

    14 May 2019

Funded under:

H2020-EU.3.2.

  • Overall budget:

    € 8 821 295,56

  • EU contribution

    € 7 999 097

Coordinated by:

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

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