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Aging Lungs in European Cohorts

Objective

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies.

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action
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Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 567 232

Participants (10)

UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 401 243,75
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
EU contribution
€ 496 026
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 550 000
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 394 712,50
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 0
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 405 000
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
LANDSPITALI UNIVERSITY HOSPITAL
Iceland
EU contribution
€ 125 000
Address
Eiriksgata 5
101 Reykjavik
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 215 880
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 379 000
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF MELBOURNE
Australia
EU contribution
€ 0
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne
Activity type
Higher or Secondary Education Establishments