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Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

Objective

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 205 976,35

Participants (16)

UNIVERSITEIT GENT
Belgium
EU contribution
€ 468 425
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSMEDIZIN ROSTOCK
Germany
EU contribution
€ 387 500
Address
Schillingallee 35
18055 Rostock
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 308 500
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 621 995,15
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 173 250
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
AARHUS UNIVERSITET
Denmark
EU contribution
€ 500 317,50
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
BIOPOLIS SL
Spain
EU contribution
€ 532 075
Address
Calle Catedratico Agustin Escardino 9
46980 Paterna Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 0
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP
United States
EU contribution
€ 361 634,25
Address
3451 Walnut Street Room P 221
19104 Philadelphia
Activity type
Higher or Secondary Education Establishments
AnalytiCon Discovery GmbH
Germany
EU contribution
€ 533 531,25
Address
Hermannswerder Haus 17
14473 Potsdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TSINGHUA UNIVERSITY
China
EU contribution
€ 0
Address
Qing Hua Yuan
100084 Beijing
Activity type
Higher or Secondary Education Establishments
AGILENT TECHNOLOGIES BELGIUM NV
Belgium
EU contribution
€ 188 437,50
Address
De Kleetlaan 5
1831 Diegem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 507 250
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
ABIOMICS EUROPE KFT
Hungary
EU contribution
€ 347 312,50
Address
Zolyomi Ut 23
1118 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TARTU ULIKOOL
Estonia
EU contribution
€ 185 750
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 251 726
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments