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Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

Objective

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.
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Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN

Address

Oude Markt 13
3000 Leuven

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 304 400

Participants (17)

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UNIVERSITEIT GENT

Belgium

EU Contribution

€ 468 425

UNIVERSITATSMEDIZIN ROSTOCK

Germany

EU Contribution

€ 387 500

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 308 500

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany

EU Contribution

€ 566 250

TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 173 250

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 500 317,50

BIOPOLIS SL

Spain

EU Contribution

€ 532 075

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

University of Pennsylvania

United States

EU Contribution

€ 318 956

AnalytiCon Discovery GmbH

Germany

EU Contribution

€ 533 531

TSINGHUA UNIVERSITY

China

CARTAGENIA NV

Belgium

AGILENT TECHNOLOGIES BELGIUM NV

Belgium

EU Contribution

€ 188 437,50

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 507 250

ABIOMICS EUROPE KFT

Hungary

EU Contribution

€ 347 312,50

TARTU ULIKOOL

Estonia

EU Contribution

€ 185 750

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 251 726

Project information

Grant agreement ID: 633589

Status

Ongoing project

  • Start date

    1 May 2015

  • End date

    30 April 2020

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 7 305 146

  • EU contribution

    € 6 573 680,50

Coordinated by:

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium