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Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging

Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging

Objective

The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive function), and social, occupational, and other modifiable lifestyle factors. Many exposures apply from throughout life, and potential exposure to a sub-optimal GPA lead to a cumulative risk of ill health and decreased economic prospects for the ageing. Understanding these factors, interactions and extent they contribute to the preservation of glucose homeostasis and psychosocial functioning is important for the development of preventive and therapeutic measures promoting healthy and active ageing. DynaHEALTH will contribute to implementing a dynamic model for early GPA risk identification and validation, allowing development of risk-based prevention tools and policies that will help to inform policy makers on the best periods to invest in cost-effective and sustainable healthcare strategies. DynaHEALTH comprises 13 partners from academic/private sectors and will leverage data from 21 birth cohorts and intervention studies, involving 1.5 million Europeans. By identifying biological and psychosocial determinants of the GPA and characterising metabolic and epigenetic factors, whilst quantifying the impact of exposure to an optimal lifelong GPA, DynaHEALTH will influence weight gain, glucose homeostasis, employability, health deterioration and disease accumulation as individuals age. DynaHEALTH includes the potential to exploit the results for new technologies and strategies, adding to our understanding of pathways related to healthy and active ageing, underpinning options for targeted, personalised healthcare and mitigating the effects of sub-optimal GPA on ageing.
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Coordinator

OULUN YLIOPISTO

Address

Pentti Kaiteran Katu 1
90014 Oulu

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 877 663,14

Participants (13)

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BETA TECHNOLOGY LTD

United Kingdom

EU Contribution

€ 250 336

SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF

Finland

EU Contribution

€ 495 366,25

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 368 527,98

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 322 450

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 640 501

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 568 907,15

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 372 453,75

UNIVERSIDAD DE GRANADA

Spain

EU Contribution

€ 555 990

LABORATORIOS ORDESA SL

Spain

EU Contribution

€ 15 660

ABBOTT LABORATORIES SA

Spain

EU Contribution

€ 78 160

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 720 160

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands

EU Contribution

€ 625 000

BRUNEL UNIVERSITY LONDON

United Kingdom

EU Contribution

€ 26 090,23

Project information

Grant agreement ID: 633595

Status

Closed project

  • Start date

    1 April 2015

  • End date

    31 March 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 918 766,27

  • EU contribution

    € 5 917 265,50

Coordinated by:

OULUN YLIOPISTO

Finland