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Lifecourse biological pathways underlying social differences in healthy ageing

Project information

Grant agreement ID: 633666

Status

Closed project

  • Start date

    1 May 2015

  • End date

    30 April 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 7 259 113,16

  • EU contribution

    € 5 999 756

Coordinated by:

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

Objective

"The dramatic differentials in healthy ageing, quality of life and life expectancy between individuals of different socioeconomic groups, is a major societal challenge facing Europe. The overarching aim of the LIFEPATH project is to understand the determinants of diverging ageing pathways among individuals belonging to different socio-economic groups. This will be achieved via an original study design that integrates social science approaches with biology (including molecular epidemiology), using existing population cohorts and omics measurements (particularly epigenomics). The specific objectives of the project are: (a) To show that healthy ageing is an achievable goal for society, as it is already experienced by individuals of high socio-economic status (SES); (b) To improve the understanding of the mechanisms through which healthy ageing pathways diverge by SES, by investigating lifecourse biological pathways using omic technologies; (c) To examine the consequences of the current economic recession on health and the biology of ageing (and the consequent increase in social inequalities); (d) To provide updated, relevant and innovative evidence for healthy ageing policies (particularly “health in all policies”) that address social disparities in ageing and the social determinants of health, using both observational studies as well as an experimental approach based on the existing ""conditional cash transfer"" experiment in New York.
To achieve these objectives we will use data from three categories of studies: 1. Europe-wide or national surveys combined with population registry data; 2. Cohorts with intense phenotyping and repeat biological samples (total population >33,000); 3. Large cohorts with biological samples (total population >202,000). The cohorts will provide information on healthy ageing at different stages of life, based on the concepts of life-course epidemiology (""build-up and decline"") and multimorbidity.
"

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Address

South Kensington Campus Exhibition Road
Sw7 2az London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 936 050

Participants (16)

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 474 831

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland

UNIVERSITE PAUL SABATIER TOULOUSE III

France

EU Contribution

€ 351 500

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 702 812,50

LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE

United Kingdom

TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

United States

EU Contribution

€ 201 250

TYOTERVEYSLAITOS

Finland

EU Contribution

€ 155 065,73

IIGM FOUNDATION

Italy

EU Contribution

€ 1 051 500

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 232 585

INSTITUTO DE SAUDE PUBLICA DA UNIVERSIDADE DO PORTO

Portugal

EU Contribution

€ 210 200

CANCER COUNCIL VICTORIA

Australia

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 330 202,50

UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU Contribution

€ 162 125

ZADIG SRL

Italy

EU Contribution

€ 326 062,50

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 358 043,75

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 507 528,02

Project information

Grant agreement ID: 633666

Status

Closed project

  • Start date

    1 May 2015

  • End date

    30 April 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 7 259 113,16

  • EU contribution

    € 5 999 756

Coordinated by:

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom