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Secondary prEvention of CardiovascUlaR disease in the Elderly trial

Objective

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adherence reduces their effectiveness and is the primary reason for suboptimal clinical benefit, contributing significantly to worsening of diseases and deaths at the population level. SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for secondary prevention of cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke, and hospitalisation requiring revascularisation) as compared to standard therapy (the three components of the polypill given separately). As part of the secondary endpoints, SECURE will compare the effect of both strategies on adherence and intermediate measures of risk factor control such as lipids and blood pressure. Importantly, it will also measure the pharmacoeconomic impact of the FDC intervention as well as regional differences in all outcomes. The five-year project will thus involve subjects from seven different countries: Spain, Italy, France, Germany, Hungary, Poland and the Czech Republic. The findings and conclusions obtained in SECURE will allow the drafting of clinical guidelines and recommendations that will provide useful guidance and will serve as a reference framework for all stakeholders involved in tackling major challenges related to secondary prevention and treatment of chronic diseases in the elderly population.
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Coordinator

CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)

Address

Calle Melchor Fernandez Almagro 3
28029 Madrid

Spain

Activity type

Research Organisations

EU Contribution

€ 1 465 972

Participants (10)

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ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 1 034 362,50

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 1 096 546,25

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON

France

EU Contribution

€ 232 609

UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU

Poland

EU Contribution

€ 211 251

SEMMELWEIS EGYETEM

Hungary

EU Contribution

€ 184 650

VSEOBECNA FAKULTNI NEMOCNICE V PRAZE

Czechia

EU Contribution

€ 219 883,75

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 794 166,25

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU Contribution

€ 104 258,75

ARTTIC

France

EU Contribution

€ 391 512,50

FERRER INTERNATIONAL

Spain

EU Contribution

€ 263 574

Project information

Grant agreement ID: 633765

Status

Ongoing project

  • Start date

    1 May 2015

  • End date

    31 December 2021

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 6 898 301,50

  • EU contribution

    € 5 998 786

Coordinated by:

CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)

Spain