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Secondary prEvention of CardiovascUlaR disease in the Elderly trial

Objective

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adherence reduces their effectiveness and is the primary reason for suboptimal clinical benefit, contributing significantly to worsening of diseases and deaths at the population level. SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for secondary prevention of cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke, and hospitalisation requiring revascularisation) as compared to standard therapy (the three components of the polypill given separately). As part of the secondary endpoints, SECURE will compare the effect of both strategies on adherence and intermediate measures of risk factor control such as lipids and blood pressure. Importantly, it will also measure the pharmacoeconomic impact of the FDC intervention as well as regional differences in all outcomes. The five-year project will thus involve subjects from seven different countries: Spain, Italy, France, Germany, Hungary, Poland and the Czech Republic. The findings and conclusions obtained in SECURE will allow the drafting of clinical guidelines and recommendations that will provide useful guidance and will serve as a reference framework for all stakeholders involved in tackling major challenges related to secondary prevention and treatment of chronic diseases in the elderly population.

Call for proposal

H2020-PHC-2014-2015

See other projects for this call

Sub call

H2020-PHC-2014-two-stage

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Net EU contribution
€ 1 465 972,00
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
Non-EU contribution
€ 128 403,00
Region
Comunidad de Madrid Comunidad de Madrid Madrid

Participants (11)

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Net EU contribution
€ 1 034 362,50
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 1 096 546,25
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON
France
Net EU contribution
€ 232 609,00
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Bourgogne-Franche-Comté Franche-Comté Doubs
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
Net EU contribution
€ 211 251,00
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SEMMELWEIS EGYETEM
Hungary
Net EU contribution
€ 184 650,00
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VSEOBECNA FAKULTNI NEMOCNICE V PRAZE
Czechia
Net EU contribution
€ 219 883,75
Address
U Nemocnice 2
12808 Praha 2
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Region
Praha Hlavní město Praha
 
SERVICIO MADRILENO DE SALUD
Spain
Net EU contribution
€ 587 938,75
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO CLINICO SAN CARLOS
Spain
Net EU contribution
€ 206 227,50
Address
Calle Profesor Martin Lagos
28040 Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Comunidad de Madrid Comunidad de Madrid Madrid
 
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
Net EU contribution
€ 104 258,75
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
London Inner London — West Camden and City of London
ARTTIC
France
Net EU contribution
€ 391 512,50
Address
39 Rue Des Mathurins
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FERRER INTERNACIONAL SA
Spain
Net EU contribution
€ 263 574,00
Address
Gran Via De Carlos Iii 94
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 771 112,50