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Secondary prEvention of CardiovascUlaR disease in the Elderly trial

Objective

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adherence reduces their effectiveness and is the primary reason for suboptimal clinical benefit, contributing significantly to worsening of diseases and deaths at the population level. SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for secondary prevention of cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke, and hospitalisation requiring revascularisation) as compared to standard therapy (the three components of the polypill given separately). As part of the secondary endpoints, SECURE will compare the effect of both strategies on adherence and intermediate measures of risk factor control such as lipids and blood pressure. Importantly, it will also measure the pharmacoeconomic impact of the FDC intervention as well as regional differences in all outcomes. The five-year project will thus involve subjects from seven different countries: Spain, Italy, France, Germany, Hungary, Poland and the Czech Republic. The findings and conclusions obtained in SECURE will allow the drafting of clinical guidelines and recommendations that will provide useful guidance and will serve as a reference framework for all stakeholders involved in tackling major challenges related to secondary prevention and treatment of chronic diseases in the elderly population.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids
  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 1 465 972

Participants (10)

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 1 034 362,50
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 1 096 546,25
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON
France
EU contribution
€ 232 609
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
EU contribution
€ 211 251
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 184 650
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
VSEOBECNA FAKULTNI NEMOCNICE V PRAZE
Czechia
EU contribution
€ 219 883,75
Address
U Nemocnice 2
12808 Praha 2
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 794 166,25
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 104 258,75
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
ARTTIC
France
EU contribution
€ 391 512,50
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FERRER INTERNATIONAL
Spain
EU contribution
€ 263 574
Address
Avenida Diagonal 549
08029 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)