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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Objective

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer.
The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies.
The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Net EU contribution
€ 925 687,50
Address
Plesmanlaan 121
1066 CX Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (12)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Net EU contribution
€ 383 306,25
Address
Old Brompton Road 123
SW7 3RP London

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 1 056 118,75
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 350 000,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
Net EU contribution
€ 268 750,00
Address
Im Neuenheimer Feld 280
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 399 000,00
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO PARC CIENTIFIC DE BARCELONA

Participation ended

Spain
Net EU contribution
€ 0,00
Address
Baldiri I Reixac 4
08028 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VIB VZW
Belgium
Net EU contribution
€ 63 750,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
Net EU contribution
€ 228 618,75
Address
Worts Causeway 2
CB1 8RN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE LAVAL
Canada
Net EU contribution
€ 0,00
Address
Allee Des Bibliotheques 2345
G1V 0A6 Quebec

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 37 500,00
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Net EU contribution
€ 0,00
Non-EU contribution
€ 37 500,00
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
Net EU contribution
€ 0,00
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge

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Activity type
Research Organisations
Non-EU contribution
€ 62 500,00
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
Net EU contribution
€ 2 308 125,00
Address
Carrer Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00