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ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS
Address
Viale Medaglie D'oro 305
00136 Rome
Italy
Activity type
Research Organisations
EU contribution
€ 833 487,50

Participants (12)

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU contribution
€ 972 708,75
Address
Giefinggasse 4
1210 Wien
Activity type
Research Organisations
USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I.
Czechia
EU contribution
€ 313 125
Address
Kobylisy Chaberska 57
182 51 Praha 8
Activity type
Research Organisations
ISTITUTI FISIOTERAPICI OSPITALIERI
Italy
EU contribution
€ 407 375
Address
Via Chianesi 53
00144 Roma
Activity type
Other
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 343 750
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET SIEGEN
Germany
EU contribution
€ 307 300
Address
Adolf Reichwein Strasse 2A
57076 Siegen
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
EU contribution
€ 213 750
Address
Via Ariosto 35
44121 Ferrara
Activity type
Higher or Secondary Education Establishments
Teknologian tutkimuskeskus VTT Oy
Finland
EU contribution
€ 630 536,25
Address
Vuorimiehentie 3
02150 Espoo
Activity type
Research Organisations
SCRIBA NANOTECNOLOGIE SRL
Italy
EU contribution
€ 270 250
Address
Via Di Corticella 183/8
40128 Bologna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GINOLIS OY
Finland
EU contribution
€ 403 125
Address
Automaatiotie 1
90460 Oulunsalo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE DIAGNOSTICS SOLUTIONS BV
Netherlands
EU contribution
€ 524 375
Address
Nieuweweg 279
6603 BN Wijchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HORIBA FRANCE SAS
France
EU contribution
€ 646 922,50
Address
Rue Du Canal 16-18
91160 Longjumeau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AMIRES SRO
Czechia
EU contribution
€ 159 750
Address
Stavitelska 1099/6
160 00 Praha 6
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)