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ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

ISTITUTO NAZIONALE DI BIOSTRUTTURE E BIOSISTEMI
Net EU contribution
€ 506 135,00
Address
Viale Medaglie D'oro 305
00136 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (18)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DEGLI STUDI DI PARMA
Italy
Net EU contribution
€ 105 795,00
Address
Via Universita 12
43100 Parma

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Region
Nord-Est Emilia-Romagna Parma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DEGLI STUDI DI CATANIA
Italy
Net EU contribution
€ 197 932,50
Address
Piazza Universita 2
95131 Catania

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Region
Isole Sicilia Catania
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
Net EU contribution
€ 23 625,00
Address
Piazza San Marco 4
50121 Florence

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Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
Net EU contribution
€ 966 458,75
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SEIBERSDORF LABOR GMBH
Austria
Net EU contribution
€ 6 250,00
Address
Forschungszentrum
2444 Seibersdorf

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Region
Niederösterreich Wiener Umland/Südteil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I.
Czechia
Net EU contribution
€ 313 125,00
Address
Kobylisy Chaberska 57
182 51 Praha 8

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ISTITUTI FISIOTERAPICI OSPITALIERI
Italy
Net EU contribution
€ 407 375,00
Address
Via Chianesi 53
00144 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSITEIT TWENTE
Netherlands
Net EU contribution
€ 343 750,00
Address
Drienerlolaan 5
7522 NB Enschede

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Region
Oost-Nederland Overijssel Twente
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET SIEGEN
Germany
Net EU contribution
€ 307 300,00
Address
Adolf Reichwein Strasse 2a
57076 Siegen

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Region
Nordrhein-Westfalen Arnsberg Siegen-Wittgenstein
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
Net EU contribution
€ 213 750,00
Address
Via Ariosto 35
44121 Ferrara

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Region
Nord-Est Emilia-Romagna Ferrara
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
Finland
Net EU contribution
€ 630 536,25
Address
Tekniikantie 21
02150 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SCRIBA NANOTECNOLOGIE SRL
Italy
Net EU contribution
€ 270 250,00
Address
Via Di Corticella 183/8
40128 Bologna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Emilia-Romagna Bologna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
GINOLIS OY
Finland
Net EU contribution
€ 276 250,00
Address
Automaatiotie 1
90460 Oulunsalo

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

GINOLIS AB
Sweden
Net EU contribution
€ 126 875,00
Address
Vallvagen 4b
756 51 Uppsala

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUTURE DIAGNOSTICS SOLUTIONS BV
Netherlands
Net EU contribution
€ 524 375,00
Address
Nieuweweg 279
6603 BN Wijchen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
HORIBA FRANCE SAS
France
Net EU contribution
€ 610 922,50
Address
14 Boulevard Thomas Gobert Passage Jobin Yvon Cs 4
91120 Palaiseau

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HORIBA ABX SAS
France
Net EU contribution
€ 36 000,00
Address
Rue Du Caducee Parc Euromedecine
34000 Montpellier

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AMIRES SRO
Czechia
Net EU contribution
€ 159 750,00
Address
Na Okraji 335/42
162 00 Praha 6

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Praha Hlavní město Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00