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ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.
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Coordinator

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Address

Viale Medaglie D'Oro 305
00136 Rome

Italy

Activity type

Research Organisations

EU Contribution

€ 833 487,50

Participants (12)

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AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU Contribution

€ 972 708,75

USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I.

Czechia

EU Contribution

€ 313 125

ISTITUTI FISIOTERAPICI OSPITALIERI

Italy

EU Contribution

€ 407 375

UNIVERSITEIT TWENTE

Netherlands

EU Contribution

€ 343 750

UNIVERSITAET SIEGEN

Germany

EU Contribution

€ 307 300

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

EU Contribution

€ 213 750

Teknologian tutkimuskeskus VTT Oy

Finland

EU Contribution

€ 630 536,25

SCRIBA NANOTECNOLOGIE SRL

Italy

EU Contribution

€ 270 250

GINOLIS OY

Finland

EU Contribution

€ 403 125

FUTURE DIAGNOSTICS SOLUTIONS BV

Netherlands

EU Contribution

€ 524 375

HORIBA FRANCE SAS

France

EU Contribution

€ 646 922,50

AMIRES SRO

Czechia

EU Contribution

€ 159 750

Project information

Grant agreement ID: 633937

Status

Closed project

  • Start date

    1 May 2015

  • End date

    31 October 2018

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 6 026 455

  • EU contribution

    € 6 026 455

Coordinated by:

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Italy