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Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Objective

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.
The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000.
Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.
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Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA

Address

Camino De Vera Sn Edificio 3a
46022 Valencia

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 097 891

Participants (10)

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FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 409 050

UNIVERSITEIT TWENTE

Netherlands

EU Contribution

€ 423 731

AALBORG UNIVERSITET

Denmark

EU Contribution

€ 344 915

CDA GMBH

Germany

EU Contribution

€ 336 537,50

EV GROUP E. THALLNER GMBH

Austria

EU Contribution

€ 257 650

BIONOS BIOTECH SL

Spain

EU Contribution

€ 227 000

ART OF TECHNOLOGY AG

Switzerland

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

EU Contribution

€ 315 937,50

GENERA BIOTECH SL

Spain

EU Contribution

€ 49 734,44

DB VENTURE BUILDER SL

Spain

EU Contribution

€ 131 515,56

Project information

Grant agreement ID: 634013

Status

Closed project

  • Start date

    1 September 2015

  • End date

    28 February 2019

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 4 146 163,75

  • EU contribution

    € 3 593 962

Coordinated by:

UNIVERSITAT POLITECNICA DE VALENCIA

Spain