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Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Objetivo

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.
The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000.
Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

Convocatoria de propuestas

H2020-PHC-2014-two-stage
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Régimen de financiación

RIA - Research and Innovation action

Coordinador

UNIVERSITAT POLITECNICA DE VALENCIA
Dirección
Camino De Vera Sn Edificio 3A
46022 Valencia
España
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 097 891

Participantes (10)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Alemania
Aportación de la UE
€ 409 050
Dirección
Hansastrasse 27C
80686 Munchen
Tipo de actividad
Research Organisations
UNIVERSITEIT TWENTE
Países Bajos
Aportación de la UE
€ 423 731
Dirección
Drienerlolaan 5
7522 NB Enschede
Tipo de actividad
Higher or Secondary Education Establishments
AALBORG UNIVERSITET
Dinamarca
Aportación de la UE
€ 344 915
Dirección
Fredrik Bajers Vej 7K
9220 Aalborg
Tipo de actividad
Higher or Secondary Education Establishments
CDA GMBH
Alemania
Aportación de la UE
€ 336 537,50
Dirección
Am Mittelrain 11
98529 Suhl Ot Albrechts
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EV GROUP E. THALLNER GMBH
Austria
Aportación de la UE
€ 257 650
Dirección
Di Erich Thallner Strasse 1
4782 St Florian Am Inn
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIONOS BIOTECH SL
España
Aportación de la UE
€ 227 000
Dirección
Bulev Sur S/n - Biopolo La Fe Edificio Torre A Ho
46029 Valencia
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ART OF TECHNOLOGY AG
Suiza
Aportación de la UE
€ 0
Dirección
Technoparkstrasse 1
8005 Zurich
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Aportación de la UE
€ 315 937,50
Dirección
Cranmer Terrace
SW17 0RE London
Tipo de actividad
Higher or Secondary Education Establishments
GENERA BIOTECH SL

La participación finalizó

España
Aportación de la UE
€ 49 734,44
Dirección
C/ Catedratico Agustin Escardino 9
46980 Paterna Valencia
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DB VENTURE BUILDER SL
España
Aportación de la UE
€ 131 515,56
Dirección
Calle Antonio Suarez 27 1 1
46021 Valencia
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)