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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Objective

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

VIB VZW
Net EU contribution
€ 576 750,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 0,00

Participants (9)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 490 680,00
Address
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 144 052,75
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 420 812,50
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 340 750,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 118 375,00
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 364 520,00
Address
Nethergate
DD1 4HN Dundee

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Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAETSKLINIKUM ESSEN
Germany
Net EU contribution
€ 347 038,75
Address
Hufelandstrasse 55
45147 Essen

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Region
Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Idea Bio-Medical Ltd.
Israel
Net EU contribution
€ 62 625,00
Address
Prof. Bergman St. 2
76705 Rehovot

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Net EU contribution
€ 133 750,00
Address
1 Midland Road
NW1 1AT London

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 0,00