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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Objective

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.

Field of science

  • /natural sciences/computer and information sciences/data science/data exchange
  • /social sciences/sociology/social problems/migration
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

VIB VZW
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium
Activity type
Research Organisations
EU contribution
€ 576 750

Participants (9)

WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 490 680
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 144 052,75
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 420 812,50
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 340 750
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 118 375
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 364 520
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 347 038,75
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Idea Bio-Medical Ltd.
Israel
EU contribution
€ 62 625
Address
Prof. Bergman St. 2
76705 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
EU contribution
€ 133 750
Address
1 Midland Road
NW1 1AT London
Activity type
Research Organisations