Periodic Reporting for period 2 - MULTIMOT (Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT))
Reporting period: 2017-02-01 to 2018-07-31
The MULTIMOT project has also created the Cell Migration Standardization Organization (CMSO; http://www.cmso.science) which hosts a community that is developing community-based standards for cell migration researchers. The CMSO has produced the three key standards required for the field (minimal reporting requirements, controlled vocabularies, and a data format), and we have also built the associated software libraries to read from, and write to these formats. At the same time, the central data repository for cell migration data has progressed to beta stage, with a clear view to a first release in a few months (according to schedule). In order to make the most of cell migration data, we have developed a powerful, open source, cross-platform tool called CellMojo (complete with user-friendly graphical user interface) to process the raw images in a migration movie into a large set of individual cell tracks, and we have supplemented this with a considerable update to the CellMissy software (https://github.com/compomics/cellmissy) that allows it to perform downstream analysis of these single cell tracks. On the experimental side, we have firmly established the two model systems for personalized medicine on which the second part of the project will build, and we have started the analysis and processing of data from these model systems. Throughout, we have communicated clearly and openly with the community, predominantly through active interactions via the CMSO.