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Fast Assay for Pathogen Identification and Characterisation

Objective

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours.
The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day.
In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 718 978

Participants (9)

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU contribution
€ 1 339 696
Address
Giefinggasse 4
1210 Wien
Activity type
Research Organisations
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 555 654
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET
Croatia
EU contribution
€ 91 250
Address
Salata 3
10 000 Zagreb
Activity type
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 101 865
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT HASSELT
Belgium
EU contribution
€ 315 504
Address
Martelarenlaan 42
3500 Hasselt
Activity type
Higher or Secondary Education Establishments
AXO SCIENCE SAS
France
EU contribution
€ 1 052 675
Address
Rue Du Mail 34
69004 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MOLZYM GMBH & CO KG
Germany
EU contribution
€ 909 750
Address
Mary-astell-strasse 10
28359 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BEE ROBOTICS LTD
United Kingdom
EU contribution
€ 770 875
Address
Unit 32/33 Cibyn Ind Estate
LL55 2BD Caernarfon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LYON INGENIERIE PROJETS
France
EU contribution
€ 143 750
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)