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Fast Assay for Pathogen Identification and Characterisation

Fast Assay for Pathogen Identification and Characterisation

Objective

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours.
The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day.
In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.
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Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD

Address

Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 718 978

Participants (9)

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AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU Contribution

€ 1 352 496

THE UNIVERSITY OF WARWICK

United Kingdom

EU Contribution

€ 540 654

SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET

Croatia

EU Contribution

€ 91 250

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 80 865

UNIVERSITEIT HASSELT

Belgium

EU Contribution

€ 336 504

AXO SCIENCE SAS

France

EU Contribution

€ 1 041 875

MOLZYM GMBH & CO KG

Germany

EU Contribution

€ 914 750

BEE ROBOTICS LTD

United Kingdom

EU Contribution

€ 775 875

LYON INGENIERIE PROJETS

France

EU Contribution

€ 146 750

Project information

Grant agreement ID: 634137

Status

Ongoing project

  • Start date

    1 May 2015

  • End date

    30 April 2020

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 5 999 997

  • EU contribution

    € 5 999 997

Coordinated by:

UNIVERSITE LYON 1 CLAUDE BERNARD

France